Gender differences in risk factors for high plasma homocysteine levels based on a retrospective checkup cohort using a generalized estimating equation analysis
机构：[1]Health Management Department, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.首都医科大学宣武医院[2]Information Center, Xuanwu Hospital, Capital Medical University, Beijing, China.首都医科大学宣武医院[3]Department of Evidence-based Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.首都医科大学宣武医院[4]Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China首都医科大学宣武医院
Background Hyperhomocysteinemia (HHcy) is associated with various health problems, but less is known about the gender differences in risk factors for high plasma homocysteine (Hcy) levels. Methods In this study, a retrospective study was carried out on 14,911 participants (7838 males and 7073 females) aged 16-102 years who underwent routine checkups between January 2012 and December 2017 in the Health Management Department of Xuanwu Hospital, China. Anthropometric measurements, including body mass index (BMI) and waist-to-hip ratio, were collected. Fasting blood samples were collected to measure the biochemical indexes. The outcome variable was Hcy level, and a generalized estimating equation (GEE) analysis was used to identify the associations of interest based on gender. Results Males exhibited increased Hcy levels (16.37 +/- 9.66 vs 11.22 +/- 4.76 mu mol/L) and prevalence of HHcy (37.0% vs 11.3%) compared with females. Hcy levels and HHcy prevalence increased with age in both genders, except for the 16- to 29-year-old group. GEE analysis indicated that irrespective of gender, aspartate aminotransferase, creatinine, uric acid, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels were positively correlated with Hcy levels, and alanine aminotransferase, total cholesterol and glucose were negatively correlated with Hcy levels. However, age, BMI and triglycerides (TGs) were positively correlated with Hcy levels exclusively in females. Conclusions Gender differences in risk factors for high plasma Hcy levels were noted. Although common correlational factors existed in both genders, age, BMI and TGs were independent risk factors for Hcy levels specifically in females.
基金：
Beijing Municipal Key Laboratory of Clinical Epidemiology, China; National Natural Science Foundation of China, ChinaNational Natural Science Foundation of China (NSFC) [81971200]
第一作者机构：[1]Health Management Department, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.
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推荐引用方式(GB/T 7714)：
Zhao Jing,Li Zhihua,Hou Chengbei,et al.Gender differences in risk factors for high plasma homocysteine levels based on a retrospective checkup cohort using a generalized estimating equation analysis[J].LIPIDS IN HEALTH AND DISEASE.2021,20(1):doi:10.1186/s12944-021-01459-z.
APA：
Zhao, Jing,Li, Zhihua,Hou, Chengbei,Sun, Fei,Dong, Jing...&Guo, Yansu.(2021).Gender differences in risk factors for high plasma homocysteine levels based on a retrospective checkup cohort using a generalized estimating equation analysis.LIPIDS IN HEALTH AND DISEASE,20,(1)
MLA：
Zhao, Jing,et al."Gender differences in risk factors for high plasma homocysteine levels based on a retrospective checkup cohort using a generalized estimating equation analysis".LIPIDS IN HEALTH AND DISEASE 20..1(2021)
