机构：[1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China,医技科室放射科首都医科大学宣武医院[2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China, [3]Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China, 神经科系统神经外科功能神经外科首都医科大学宣武医院[4] Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China, 神经科系统神经内科首都医科大学宣武医院[5]UIH America, Inc., Houston, TX, United States,[6]Central Research Institute, UIH Group, Shanghai, China
Objective To investigate iron deposition in the substantia nigra (SN) of Parkinson's disease (PD) patients associated with levodopa-induced dyskinesia (LID). Methods Seventeen PD patients with LID, 17 PD patients without LID, and 16 healthy controls were recruited for this study. The mean QSM values of the whole, left, and right SN were compared among the three groups. A multivariate logistic regression model was constructed to determine the factors associated with increased risk of LID. The receiver operating characteristic curve of the QSM value of SN in discriminating PD with and without LID was evaluated. Results The mean QSM values of the whole and right SN in the PD with LID were higher than those in the PD without LID (*P = 0.03, *P = 0.03). Multivariate logistic regression analysis revealed that the QSM value of whole, left, or right SN was a predictor of the development of LID (*P = 0.03, *P = 0.04, and *P = 0.04). The predictive accuracy of LID in adding the QSM value of the whole, left, and right SN to LID-related clinical risk factors was 70.6, 64.7, and 67.6%, respectively. The QSM cutoff values between PD with and without LID of the whole, left, and right SN were 148.3, 165.4, and 152.7 ppb, respectively. Conclusion This study provides the evidence of higher iron deposition in the SN of PD patients with LID than those without LID, suggesting that the QSM value of the SN may be a potential early diagnostic neuroimaging biomarker for LID.
基金：
Beijing Municipal Administration of Hospitals' Ascent Plan [DFL20180802]; Wu Jieping Medical Foundation [320.6750.19089-78]
第一作者机构：[1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China,[2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China,[2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China,
推荐引用方式(GB/T 7714)：
Song Tianbin,Li Jiping,Mei Shanshan,et al.Nigral Iron Deposition Is Associated With Levodopa-Induced Dyskinesia in Parkinson's Disease[J].FRONTIERS IN NEUROSCIENCE.2021,15:doi:10.3389/fnins.2021.647168.
APA：
Song, Tianbin,Li, Jiping,Mei, Shanshan,Jia, Xiaofei,Yang, Hongwei...&Lu, Jie.(2021).Nigral Iron Deposition Is Associated With Levodopa-Induced Dyskinesia in Parkinson's Disease.FRONTIERS IN NEUROSCIENCE,15,
MLA：
Song, Tianbin,et al."Nigral Iron Deposition Is Associated With Levodopa-Induced Dyskinesia in Parkinson's Disease".FRONTIERS IN NEUROSCIENCE 15.(2021)
