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Characterizing the seizure onset zone and epileptic network using EEG-fMRI in a rat seizure model.

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机构: [a]Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China [b]Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing Institute of Brain Disorders, Beijing, China [c]Neuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China [d]School of Biomedical Engineering, Capital Medical University, Beijing, China, [e]Core Facilities Center, Capital Medical University, Beijing, China [f]College of Electrical and Control Engineering, North China University of Technology, Beijing, China [g]Department of Medical Imaging, Jinling Hospital, Southern Medical University, Nanjing, China [h]Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
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关键词: EEG-fMRI Seizure Seizure onset zone Epileptogenic zone Animal model

摘要:
Accurate epileptogenic zone (EZ) or seizure onset zone (SOZ) localization is crucial for epilepsy surgery optimization. Previous animal and human studies on epilepsy have reported that changes in blood oxygen level-dependent (BOLD) signals induced by epileptic events could be used as diagnostic markers for EZ or SOZ localization. Simultaneous electroencephalography and functional magnetic resonance imaging (EEG-fMRI) recording is gaining interest as a non-invasive tool for preoperative epilepsy evaluation. However, EEG-fMRI studies have reported inconsistent and ambiguous findings. Therefore, it remains unclear whether BOLD responses can be used for accurate EZ or SOZ localization. In this study, we used simultaneous EEG-fMRI recording in a rat model of 4-aminopyridine-induced acute focal seizures to assess the spatial concordance between individual BOLD responses and the SOZ. This was to determine the optimal use of simultaneous EEG-fMRI recording in the SOZ localization. We observed a high spatial consistency between BOLD responses and the SOZ. Further, dynamic BOLD responses were consistent with the regions where the seizures were propagated. These results suggested that simultaneous EEG-fMRI recording could be used as a noninvasive clinical diagnostic technique for localizing the EZ or SOZ and could be an effective tool for mapping epileptic networks. Copyright © 2021. Published by Elsevier Inc.

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出版当年[2020]版:
大类 | 2 区 医学
小类 | 1 区 神经成像 2 区 神经科学 2 区 核医学
最新[2023]版:
大类 | 2 区 医学
小类 | 1 区 神经成像 2 区 神经科学 2 区 核医学
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出版当年[2019]版:
Q1 NEUROIMAGING Q1 NEUROSCIENCES Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版:
Q1 NEUROIMAGING Q1 NEUROSCIENCES Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子: 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

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第一作者机构: [a]Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China [b]Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing Institute of Brain Disorders, Beijing, China [c]Neuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China
通讯作者:
通讯机构: [*1]Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, No. 190 Kaiyuan Blvd, Huangpu, Guangzhou, China, 510530.
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