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Long non-coding RNA H19: Physiological functions and involvements in central nervous system disorders.

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机构： [a]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China [b]Beijing Geriatric Medical Research Center and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing 100053, China [c]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100053, China

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关键词： H19 lncRNA H19 Central nervous disorders Physiological functions

摘要：

Central nervous system (CNS) disorders are some of the most complex and challenging diseases because of the intricate structure and functions of the CNS. Long non-coding RNA (LncRNA) H19, which had been mistaken for "transcription noise" previously, has now been found to be closely related to the development and homeostasis of the CNS. Several recent studies indicate that it plays an important role in the pathogenesis, treatment, and even prognosis of CNS disorders. LncRNA H19 is correlated with susceptibility to various CNS disorders such as intracranial aneurysms, ischemic stroke, glioma, and neuroblastoma. Moreover, it participates in the pathogenesis of CNS disorders by regulating transcription, translation, and signaling pathways, suggesting that it is a promising biomarker and therapeutic target for these disorders. This article reviews the functions and mechanisms of lncRNA H19 in various CNS disorders, including cerebral ischemia, cerebral hemorrhage, glioma, pituitary adenoma, neuroblastoma, Parkinson's disease, Alzheimer's disease, traumatic spinal cord injury, neuropathic pain, and temporal lobe epilepsy, to provide a theoretical basis for further research on the role of lncRNA H19 in CNS disorders.Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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出版当年[2020]版：

大类 | 2 区医学

小类 | 3 区生化与分子生物学 3 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区生化与分子生物学 3 区神经科学

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出版当年[2019]版：

Q2 NEUROSCIENCES Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q1 NEUROSCIENCES Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 4.4 最新[2023版] 3.8 最新五年平均 3.881 出版当年[2019版] 3.808 出版当年五年平均 3.994 出版前一年[2018版] 3.921 出版后一年[2020版]

第一作者：

第一作者机构： [a]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China

通讯作者：

通讯机构： [a]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China [b]Beijing Geriatric Medical Research Center and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing 100053, China [c]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100053, China [*1]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, China.

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