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Anterior thalamic stimulation improves working memory precision judgments.

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机构： [1]CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China [2]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China [3]Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [4]Comprehensive Epilepsy Center of Beijing, The Beijing Key Laboratory of Neuromodulation, Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China

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关键词： Anterior nucleus of thalamus Electrical stimulation Hippocampus Neural oscillations Working memory precision

摘要：

The anterior nucleus of thalamus (ANT) has been suggested as an extended hippocampal system. The circuit of ANT and hippocampus has been widely demonstrated to be associated with memory function. Both lesions to each region and disrupting inter-regional information flow can induce working memory impairment. However, the role of this circuit in working memory precision remains unknown.To test the role of the hippocampal-anterior thalamic pathway in working memory precision, we delivered intracranially electrical stimulation to the ANT. We hypothesize that ANT stimulation can improve working memory precision.Presurgical epilepsy patients with depth electrodes in ANT and hippocampus were recruited to perform a color-recall working memory task. Participants were instructed to point out the color they were supposed to recall by clicking a point on the color wheel, while the intracranial EEG data were synchronously recorded. For randomly selected half trials, a bipolar electrical stimulation was delivered to the ANT electrodes.We found that compared to non-stimulation trials, working memory precision judgements were significantly improved for stimulation trials. ANT electrical stimulation significantly increased spectral power of gamma (30-100 Hz) oscillations and decreased interictal epileptiform discharges (IED) in the hippocampus. Moreover, the increased gamma power during the pre-stimulus and retrieval period predicted the improvement of working memory precision judgements.ANT electrical stimulation can improve working memory precision judgements and modulate hippocampal gamma activity, providing direct evidence on the role of the human hippocampal-anterior thalamic axis in working memory precision.Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

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出版当年[2020]版：

大类 | 2 区医学

小类 | 2 区临床神经病学 2 区神经科学

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区临床神经病学 1 区神经科学

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出版当年[2019]版：

Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

最新[2023]版：

Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

影响因子： 7.6 最新[2023版] 8.2 最新五年平均 6.565 出版当年[2019版] 7.076 出版当年五年平均 6.919 出版前一年[2018版] 8.955 出版后一年[2020版]

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第一作者机构： [1]CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China [2]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China

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通讯机构： [1]CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China [2]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China [*1]CAS Key Lab of Mental Health, Institute of Psychology, 16 Lincui Rd., Chaoyang District, Beijing, 100101, China

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Anterior thalamic stimulation improves working memory precision judgments.

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