机构：[1]Department of Psychology, Tsinghua University, Haidian District, Beijing 100084, China[2]Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China外科系统麻醉手术科首都医科大学宣武医院[3]School of Psychology, Capital Normal University, Haidian District, Beijing 100048, China[4]Beijing Key Laboratory of Learning and Cognition, Capital Normal University, Beijing 100048, China[5]AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL 36849, USA[6]Department of Psychological Sciences, Auburn University, Auburn, AL 36849, USA[7]Alabama Advanced Imaging Consortium, Birmingham, AL 35233, USA[8]Center for Neuroscience, Auburn University, Auburn, AL 36849, USA[9]Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560030, India[10]Center for Brain Research, Indian Institute of Science, Bangalore 560012, India[11]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China医技科室放射科首都医科大学宣武医院[12]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Capital Medical University, Beijing 100053, China
Altered connectivity within and between the resting-state networks (RSNs) brought about by anesthetics that induce altered consciousness remains incompletely understood. It is known that the dorsal attention network (DAN) and its anticorrelations with other RSNs have been implicated in consciousness. However, the role of DAN-related functional patterns in drug-induced sedative effects is less clear. In the current study, we investigated altered functional connectivity of the DAN during midazolam-induced light sedation. In a placebo-controlled and within-subjects experimental study, fourteen healthy volunteers received midazolam or saline with a 1-week interval. Resting-state fMRI data were acquired before and after intravenous drug administration. A multiple region of interest-driven analysis was employed to investigate connectivity within and between RSNs. It was found that functional connectivity was significantly decreased by midazolam injection in two regions located in the left inferior parietal lobule and the left middle temporal area within the DAN as compared with the saline condition. We also identified three clusters in anticorrelation between the DAN and other RSNs for the interaction effect, which included the left medial prefrontal cortex, the right superior temporal gyrus, and the right superior frontal gyrus. Connectivity between all regions and DAN was significantly decreased by midazolam injection. The sensorimotor network was minimally affected. Midazolam decreased functional connectivity of the dorsal attention network. These findings advance the understanding of the neural mechanism of sedation, and such functional patterns might have clinical implications in other medical conditions related to patients with cognitive impairment.
基金：
This work was supported by the National Key Research and Development Project of
China (2020YFC2007302), Natural Science Foundation of China (grant numbers 81671065, 81873892),Beijing Nova Program (grant number 2016000021223TD07), the key research project of Academy for
Multidisciplinary Studies, Capital Normal University (JCKXYJY2019019), Beijing Municipal Science
and Technology Project of Brain Cognition and Brain Medicine (grant number Z171100000117001),
Capital Clinical Characteristic Application Research and Achievement Promotion Project of Beijing
Ministry Science and Technology Commission (grant number Z161100000516085).
第一作者机构：[1]Department of Psychology, Tsinghua University, Haidian District, Beijing 100084, China
通讯作者：
通讯机构：[3]School of Psychology, Capital Normal University, Haidian District, Beijing 100048, China[4]Beijing Key Laboratory of Learning and Cognition, Capital Normal University, Beijing 100048, China
推荐引用方式(GB/T 7714)：
Junkai Wang,Yachao Xu,Gopikrishna Deshpande,et al.The Effect of Light Sedation with Midazolam on Functional Connectivity of the Dorsal Attention Network[J].BRAIN SCIENCES.2021,11(8):doi:10.3390/brainsci11081107.
APA：
Junkai Wang,Yachao Xu,Gopikrishna Deshpande,Kuncheng Li,Pei Sun&Peipeng Liang.(2021).The Effect of Light Sedation with Midazolam on Functional Connectivity of the Dorsal Attention Network.BRAIN SCIENCES,11,(8)
MLA：
Junkai Wang,et al."The Effect of Light Sedation with Midazolam on Functional Connectivity of the Dorsal Attention Network".BRAIN SCIENCES 11..8(2021)
