The performance of the diagnostic scoring system or criteria for macrophage activation syndrome in systemic juvenile idiopathic arthritis for adult-onset Still's disease. A multicentre, case-control study in China.
机构：[1]Dept. of Rheumatology and Immunology, Peking University People’s Hospital, Beijing[2]Dept. of Haematology, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing首都医科大学附属北京友谊医院[3]Dept. of Rheumatology and Immunology, Peking University Third Hospital, Beijing[4]Dept. of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing[5]Dept. of Rheumatology and Allergy, Xuanwu Hospital Capital Medical University, Beijing内科系统风湿免疫科首都医科大学宣武医院[6]Dept. of Rheumatology, Qilu Hospital of Shandong University, Jinan, China.
To evaluate the performance of the diagnostic scoring system/criteria for macrophage activation syndrome (MAS) used in systemic juvenile idiopathic arthritis (sJIA) for adult-onset Still's disease (AOSD).This retrospective case-control study included AOSD patients with and without MAS from six hospitals in China. The cut-off values that best discriminated MAS from active AOSD were determined by receiver operating characteristic (ROC) curve analysis. The performance of the present diagnostic scoring system/criteria for sJIA-MAS was evaluated in AOSD-associated MAS. The optimal critical value of the ROC curve replaces the relevant indicators of the existing scoring system and different models were tested for sensitivity/specificity.A total of 56 AOSD-associated MAS patients (AOSD-MAS) and 112 AOSD patients without MAS matched with age and sex treated at six centres between 2007 and 2017 were enrolled. The 2016 MAS in sJIA classification criteria had an overall sensitivity of 100.0% and specificity of 80.4% for classifying AOSD-MAS. Excluding hypertriglyceridemia and substituting some other criteria with newly obtained cut-off values could increase specificity. An MS score ≥-2.1 yielded a sensitivity of 95.2% and a specificity of 76.6% in classifying AOSD-MAS. ROC curve analysis revealed that a score of -1.74 could best discriminate AOSD-MAS from AOSD without MAS. An MS score ≥-1.74 yielded a sensitivity of 93.5% and a specificity of 92.6% in diagnosing AOSD-MAS (AUC=0.96, 95%CI: 0.93-0.99, p<0.0001).The diagnostic tool for MAS in sJIA with modification appears to apply to AOSD-MAS.
基金：
National Natural Science Foundation of China (81801618, 81871281) and the Clinical Medicine Plus X - Young Scholars Project of Peking University (PKU2021LCXQ008) supported by the Fundamental Research Funds for the Central Universities.
第一作者机构：[1]Dept. of Rheumatology and Immunology, Peking University People’s Hospital, Beijing
通讯作者：
通讯机构：[1]Dept. of Rheumatology and Immunology, Peking University People’s Hospital, Beijing[*1]Department of Rheumatology and Immunology, Peking University People’s Hospital, 11 Xizhimen South Street, Xicheng District, 100044 Beijing, China
推荐引用方式(GB/T 7714)：
Yao Haihong,Wang Yini,Wang Zhao,et al.The performance of the diagnostic scoring system or criteria for macrophage activation syndrome in systemic juvenile idiopathic arthritis for adult-onset Still's disease. A multicentre, case-control study in China.[J].Clinical and experimental rheumatology.2021,39 Suppl 132(5):129-134.
APA：
Yao Haihong,Wang Yini,Wang Zhao,Zhao Jinxia,Deng Xuerong...&Li Zhan-Guo.(2021).The performance of the diagnostic scoring system or criteria for macrophage activation syndrome in systemic juvenile idiopathic arthritis for adult-onset Still's disease. A multicentre, case-control study in China..Clinical and experimental rheumatology,39 Suppl 132,(5)
MLA：
Yao Haihong,et al."The performance of the diagnostic scoring system or criteria for macrophage activation syndrome in systemic juvenile idiopathic arthritis for adult-onset Still's disease. A multicentre, case-control study in China.".Clinical and experimental rheumatology 39 Suppl 132..5(2021):129-134
