机构：[1]Department of Neurology, The First Hospital of Jilin University, Changchun, China[2]Department of Neurosurgery, Northern Jiangsu People’s Hospital, Clinical Medical College of Yangzhou University, Yangzhou, China江苏省人民医院[3]Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, China医技科室血管超声科首都医科大学宣武医院[4]Beijing Diagnostic Center of Vascular Ultrasound, Beijing, China[5]Department of Neurology, Linyi People’s Hospital, Linyi, China[6]Department of Neurology, Changchun People’s Hospital, Changchun, China
Background: We aimed to explore whether transcranial Doppler (TCD) combined with quantitative electroencephalography (QEEG) can improve prognosis evaluation in patients with a large hemispheric infarction (LHI) and to establish an accurate prognosis prediction model.Methods: We prospectively assessed 90-day mortality in patients with LHI. Brain function was monitored using TCD-QEEG at the bedside of the patient.Results: Of the 59 (55.3 +/- 10.6 years; 17 men) enrolled patients, 37 (67.3%) patients died within 90 days. The Cox regression analyses revealed that the Glasgow Coma Scale (GCS) score <= 8 [hazard ratio (HR), 3.228; 95% CI, 1.335-7.801; p = 0.009], TCD-terminal internal carotid artery as the offending vessel (HR, 3.830; 95% CI, 1.301-11.271; p = 0.015), and QEEG-a (delta + theta)/(alpha + beta) ratio >= 3 (HR, 3.647; 95% CI, 1.170-11.373; p = 0.026) independently predicted survival duration. Combining these three factors yielded an area under the receiver operating characteristic curve of 0.905 and had better predictive accuracy than those of individual variables (p < 0.05).Conclusion: TCD and QEEG complement the GCS score to create a reliable multimodal method for monitoring prognosis in patients with LHI.
基金：
This study was supported by the National Natural Science
Foundation of China (Grant No. 82102066 and No.
81971620) and the Natural Science Foundation of Jilin Science
and Technology Department (Grant No. 20210101254JC
and 20200201522JC).
第一作者机构：[1]Department of Neurology, The First Hospital of Jilin University, Changchun, China[2]Department of Neurosurgery, Northern Jiangsu People’s Hospital, Clinical Medical College of Yangzhou University, Yangzhou, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Qi Yajie,Xing Yingqi,Wang Lijuan,et al.Multimodal Monitoring in Large Hemispheric Infarction: Quantitative Electroencephalography Combined With Transcranial Doppler for Prognosis Prediction[J].FRONTIERS IN NEUROLOGY.2021,12:doi:10.3389/fneur.2021.724571.
APA：
Qi, Yajie,Xing, Yingqi,Wang, Lijuan,Zhang, Jie,Cao, Yanting...&Chen, Ying.(2021).Multimodal Monitoring in Large Hemispheric Infarction: Quantitative Electroencephalography Combined With Transcranial Doppler for Prognosis Prediction.FRONTIERS IN NEUROLOGY,12,
MLA：
Qi, Yajie,et al."Multimodal Monitoring in Large Hemispheric Infarction: Quantitative Electroencephalography Combined With Transcranial Doppler for Prognosis Prediction".FRONTIERS IN NEUROLOGY 12.(2021)
