个人科研网厅 | | 帮助
首都医科大学宣武医院知识库
高级检索
当前位置： 首页 > 详情页

Ginsenoside compound K acts via LRP1 to alleviate Amyloid β42-induced neuroinflammation in microglia by suppressing NF-κB.

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Jiao Haishan[1] * ; Jia Jianping[1,2,3,4,5,*1] ;
机构： [1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, 45 Changchun Street, Beijing, China [2]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China [3]Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing, China [4]Center of Alzheimer's Disease, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing,China [5]Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, China
出处：
DOI： 10.1016/j.bbrc.2021.12.071
ISSN：

关键词： Alzheimer's disease LRP1 Microglia Ginsenoside compound K Amyloid b42 oligomers Neuroinflammation

摘要：
Alzheimer's disease (AD), has caused a mass of disability and mortality in elder populations, which increases global health burden. There are still limited effective disease-modifying drugs. Alleviating microglia-evoked neuroinflammation has become a promising treatment strategy for AD. Ginsenoside Compound K has been demonstrated to exhibit anti-inflammatory and neuroprotective benefits. Here we measured the effects of Ginsenoside Compound K in inhibiting amyloid-induced microglia inflammation and the possible molecular mechanisms and target of action in vitro.The cytotoxicity of all chemical reagents on BV2 cells were evaluated using the MTT assay. qRT-PCR and ELISA were carried out to detect the inflammatory cytokines levels. Western blot was utilized to determine the effect of Ginsenoside Compound K on the nuclear factor-κB (NF-κB) p65 nuclear translocation. Antagonist Receptor Associated Protein (RAP) was used to verify the engagement of low-density lipoprotein receptor-related protein 1(LRP1).Ginsenoside Compound K diminished inflammatory cytokine production and reversed NF-κB p65 nuclear translocation induced by Aβ42 oligomers. LRP1 expression was up-regulated by Ginsenoside Compound K. When LRP1 was blocked by antagonist RAP, the protective effect of Ginsenoside Compound K was massively eliminated.These observations provide evidence for anti-inflammatory effect of Ginsenoside Compound K through NF-κB pathway via LRP1 activation, and support further evaluation of Ginsenoside Compound K as a potential effective modulator for AD.Copyright © 2021. Published by Elsevier Inc.

基金：
This study was supported by the Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital. This study was supported by the Key Project of the National Natural Science Foundation of China (81530036), the National Key Scientific Instrument and Equipment Development Project (31627803), Beijing Scholars Program, Beijing Brain Initiative from Beijing Municipal Science and Technology Commission (Z2011000 05520016 and Z201100005520017), and the Key Project of the National Natural Science Foundation of China (U20A20354).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 生物学
小类 | 3 区 生物物理 4 区 生化与分子生物学
最新[2025]版：
大类 | 4 区 生物学
小类 | 4 区 生化与分子生物学 4 区 生物物理
JCR分区：
出版当年[2020]版：
Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, 45 Changchun Street, Beijing, China
通讯作者：
通讯机构： [1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, 45 Changchun Street, Beijing, China [2]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China [3]Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing, China [4]Center of Alzheimer's Disease, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing,China [5]Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, China [*1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, 45 Changchun Street, Beijing, China
推荐引用方式(GB/T 7714)：
Jiao Haishan,Jia Jianping.Ginsenoside compound K acts via LRP1 to alleviate Amyloid β42-induced neuroinflammation in microglia by suppressing NF-κB.[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2022,590:14-19.doi:10.1016/j.bbrc.2021.12.071.
APA：
Jiao Haishan&Jia Jianping.(2022).Ginsenoside compound K acts via LRP1 to alleviate Amyloid β42-induced neuroinflammation in microglia by suppressing NF-κB..BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,590,
MLA：
Jiao Haishan,et al."Ginsenoside compound K acts via LRP1 to alleviate Amyloid β42-induced neuroinflammation in microglia by suppressing NF-κB.".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 590.(2022):14-19

相关文献

[1]Ginsenoside compound K acts via LRP1 to alleviate Amyloid β42-induced neuroinflammation in microglia by suppressing NF-κB. [2]Bibliometric analysis of neuroinflammation and Alzheimer's disease [3]The miR-25802/KLF4/NF-κB signaling axis regulates microglia-mediated neuroinflammation in Alzheimer's disease [4]神经炎症、小胶质细胞与帕金森病 [5]Ginkgolide attenuates memory impairment and neuroinflammation by suppressing the NLRP3/caspase-1 pathway in Alzheimer's disease [6]TREM2, Microglia, and Alzheimer's Disease. [7]Neuroinflammation: The role and consequences [8]Association of polymorphisms in the LRP1 and A2M genes with Alzheimer's disease in the Northern Chinese Han population [9]Tetrahydroxy stilbene glycoside ameliorates neuroinflammation for Alzheimer's disease via cGAS-STING [10]Downregulation of High mobility group box 2 relieves spinal cord injury by inhibiting microglia-mediated neuroinflammation

资源点击量：17234 今日访问量：0 总访问量：925 更新日期：2025-05-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持：重庆聚合科技有限公司 地址：北京市西城区长椿街45号宣武医院