机构:[1]Tsinghua Univ, Inst Nucl & New Energy Technol, Beijing, Peoples R China[2]Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Gen Internal Med, Beijing, Peoples R China[3]Capital Med Univ, Dept ENT, Xuanwu Hosp, Beijing, Peoples R China首都医科大学宣武医院耳鼻咽喉-头颈外科外科系统[4]Capital Med Univ, Dept Pulm & Crit Care Med, Xuanwu Hosp, Beijing, Peoples R China首都医科大学宣武医院呼吸科内科系统[5]Beijing Hosp, Dept Gastroenterol, Beijing, Peoples R China[6]Capital Med Univ, Beijing Youan Hosp, Dept Liver Dis Ctr 2, Beijing, Peoples R China[7]Chongqing Tradit Chinese Med Hosp, Chongqing, Peoples R China[8]Suining Cent Hosp, Dept Med Adm, Suining, Sichuan, Peoples R China[9]Tsinghua Univ, Dept Comp Sci & Technol, Beijing, Peoples R China
Artificial intelligence (AI)-aided general clinical diagnosis is helpful to primary clinicians. Machine learning approaches have problems of generalization, interpretability, etc. Dynamic Uncertain Causality Graph (DUCG) based on uncertain casual knowledge provided by clinical experts does not have these problems. This paper extends DUCG to include the representation and inference algorithm for non-causal classification relationships. As a part of general clinical diagnoses, six knowledge bases corresponding to six chief complaints (arthralgia, dyspnea, cough and expectoration, epistaxis, fever with rash and abdominal pain) were constructed through constructing subgraphs relevant to a chief complaint separately and synthesizing them together as the knowledge base of the chief complaint. A subgraph represents variables and causalities related to a single disease that may cause the chief complaint, regardless of which hospital department the disease belongs to. Verified by two groups of third-party hospitals independently, total diagnostic precisions of the six knowledge bases ranged in 96.5-100%, in which the precision for every disease was no less than 80%.
基金:
Institute for Guo Qiang, Tsinghua University [2020QG0001]; Chongqing Science and Technology CommissionNatural Science Foundation Project of CQ CSTC [cstc2018jscx-mszdx0106]; Rockefeller-Endowed China Medical Board (Open Competition Program) [20-384]
第一作者机构:[1]Tsinghua Univ, Inst Nucl & New Energy Technol, Beijing, Peoples R China
通讯作者:
通讯机构:[1]Tsinghua Univ, Inst Nucl & New Energy Technol, Beijing, Peoples R China[9]Tsinghua Univ, Dept Comp Sci & Technol, Beijing, Peoples R China
推荐引用方式(GB/T 7714):
Zhang Zhan,Jiao Yang,Zhang Mingxia,et al.AI-aided general clinical diagnoses verified by third-parties with dynamic uncertain causality graph extended to also include classification[J].ARTIFICIAL INTELLIGENCE REVIEW.2022,55(6):4485-4521.doi:10.1007/s10462-021-10109-w.
APA:
Zhang, Zhan,Jiao, Yang,Zhang, Mingxia,Wei, Bing,Liu, Xiao...&Zhang, Qin.(2022).AI-aided general clinical diagnoses verified by third-parties with dynamic uncertain causality graph extended to also include classification.ARTIFICIAL INTELLIGENCE REVIEW,55,(6)
MLA:
Zhang, Zhan,et al."AI-aided general clinical diagnoses verified by third-parties with dynamic uncertain causality graph extended to also include classification".ARTIFICIAL INTELLIGENCE REVIEW 55..6(2022):4485-4521