机构：[1]China-America Institute of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China神经科系统神经内科首都医科大学宣武医院[2]Department of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院[3]Beijing Advanced Innovation Center for Big Data- Based Precision Medicine, School of Biological Science and Medical Engineering, Beihang University, Beijing, China[4]Department of Biomedical Engineering, Columbia University, New York City, NY, United States
Mendelian randomization was used to evaluate the potential causal association between N-terminal probrain natriuretic peptide (NT-proBNP) and ischemic stroke based on summary statistics data from large-scale genome-wide association studies. Three single-nucleotide polymorphisms (SNPs) rs198389, rs13107325, and rs11105306 associated with NT-proBNP levels found in large general populations and in patients with acute heart disease were used as instrumental variables. The results of genetic association analysis of each single SNP show that there is no significant association between NT-proBNP levels and ischemic stroke or its subtypes, whereas rs198389 alone has a suggestive association with large-artery atherosclerosis stroke. The MR analysis of three SNPs shows that NT-proBNP levels may reduce the risk of small-vessel occlusion stroke suggestively. This genetic analysis provides insights into the pathophysiology and treatment of ischemic stroke.
基金：
This work was supported by the National Natural Science Foundation
of China (Nos 82102220, 82027802, 61975017, 82071468), Beijing
Municipal Natural Science Foundation (721220) and General
Projects of Scientific and Technological Plan of Beijing Municipal
Education Commission (KM202010025023).
第一作者机构：[1]China-America Institute of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]China-America Institute of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China[2]Department of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China[3]Beijing Advanced Innovation Center for Big Data- Based Precision Medicine, School of Biological Science and Medical Engineering, Beihang University, Beijing, China
推荐引用方式(GB/T 7714)：
Li Ming,Xu Yi,Wu Jiaqi,et al.Circulating N-Terminal Probrain Natriuretic Peptide Levels in Relation to Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study[J].FRONTIERS IN GENETICS.2022,13:doi:10.3389/fgene.2022.795479.
APA：
Li, Ming,Xu, Yi,Wu, Jiaqi,Wu, Chuanjie,Li, Ang&Ji, Xunming.(2022).Circulating N-Terminal Probrain Natriuretic Peptide Levels in Relation to Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study.FRONTIERS IN GENETICS,13,
MLA：
Li, Ming,et al."Circulating N-Terminal Probrain Natriuretic Peptide Levels in Relation to Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study".FRONTIERS IN GENETICS 13.(2022)
