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Higher serum occludin after successful reperfusion Is associated with early neurological deterioration.

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机构： [1]Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China. [2]Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, China. [3]Department of General Medicine, Affiliated Hospital of Weifang Medical University, Shandong Province, China. [4]Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China. [5]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China. [6]Department of Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. [7]Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing, China.

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关键词： biomarker blood-brain barrier early neurological deterioration endovascular thrombectomy occludin stroke

摘要：

Early neurological deterioration (END) is an important factor that affects prognosis in patients with acute ischemic stroke. We explored the relationship between serum occludin levels after successful reperfusion and END in patients treated with endovascular thrombectomy (EVT).We prospectively enrolled 120 stroke patients who underwent EVT with successful reperfusion. Enzyme-linked immunosorbent assay was used to detect the serum occludin levels on admission and within 1 h after successful reperfusion. Receiver operating characteristic curves (ROC) and regression analysis were used to compare the relationship between serum occludin and END after thrombectomy.Among the 120 patients, 36 (30%) experienced END. The END group had higher serum occludin levels than the non-END group after successful reperfusion [4.31 (3.71-5.38) vs 6.32 (5.88-6.99), p < 0.001]. The ROC curve showed that postoperative serum occludin levels had a significant prediction value for END (AUC: 0.86, p < 0.001). Regression analysis showed that serum occludin was an independent risk factor for END in EVT patients (adjusted odds ratio: 4.46, 95% confidence interval: 1.92-10.32; p < 0.001).The higher serum occludin levels were strongly related to END after successful reperfusion. Serum occludin may be an independent risk factor for END in EVT patients.© 2022 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.

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出版当年[2021]版：

大类 | 2 区医学

小类 | 2 区神经科学 2 区药学

最新[2023]版：

大类 | 1 区医学

小类 | 2 区神经科学 2 区药学

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出版当年[2020]版：

Q1 PHARMACOLOGY & PHARMACY Q2 NEUROSCIENCES

最新[2023]版：

Q1 PHARMACOLOGY & PHARMACY Q1 NEUROSCIENCES

影响因子： 4.8 最新[2023版] 5.9 最新五年平均 5.243 出版当年[2020版] 4.977 出版当年五年平均 4.074 出版前一年[2019版] 7.035 出版后一年[2021版]

第一作者：

第一作者机构： [1]Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China. [2]Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, China.

通讯作者：

通讯机构： [1]Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China. [2]Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, China. [3]Department of General Medicine, Affiliated Hospital of Weifang Medical University, Shandong Province, China. [7]Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing, China. [*1]Xuanwu Hospital of Capital Medical University, Beijing, China [*2]Department of General Medicine, Affiliated Hospital of Weifang Medical University, Shandong Province, China.

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Higher serum occludin after successful reperfusion Is associated with early neurological deterioration.

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