机构：[1]Department of Neurosurgery, Guangdong Provincial People's Hospital, GuangdongInstitute of Neuroscience, Guangdong Academy of Medical Sciences, Guangzhou,Guangdong 510080, China广东省人民医院[2]Institute of Cerebrovascular Disease Research and Department of Neurology, XuanwuHospital of Capital Medical University, Beijing 100053, China[3]Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing100053, China外科系统普通外科首都医科大学宣武医院[4]Department of Neurosurgery, Uludag University School of Medicine, Bursa 16120, Turkey[5]Department of Physiology and Pharmacology, School of Medicine, Loma Linda University,Loma Linda, CA 92354, USA[6]Department of Neurosurgery, Loma Linda University, Loma Linda, CA 92354, USA[7]Beijing Geriatric Medical Research Center and Beijing Key Laboratory of TranslationalMedicine for Cerebrovascular Diseases, Beijing 100053, China.
Blood-brain barrier (BBB) disruption is a major pathological change after intracerebral hemorrhage (ICH) and is both the cause and result of oxidative stress and of the immune response post ICH. These processes contribute to ICH-induced brain injury.Following the breakdown of cerebral vessels, blood components, including erythrocytes and their metabolites, thrombin, and fibrinogen, can access the cerebral parenchyma through the compromised BBB, triggering oxidative stress and inflammatory cascades. These aggravate BBB disruption and contribute to further infiltration of blood components resulting in a vicious cycle that exacerbates brain edema and neurological injury after ICH. Experimental and clinical studies have highlighted the role of BBB disruption in ICH-induced brain injury.In this review, we focus on strategies to protect the BBB in ICH. Specifically, we summarize the evidence and the underlying mechanisms including the ICH-induced process of oxidative stress and inflammatory response, and highlight potential therapeutic targets to protect BBB integrity after ICH.Future studies should probe the mechanism of ferroptosis as well as oxidative stress-inflammation coupling in BBB disruption after ICH and investigate the effects of antioxidants and immunomodulatory agents in more ICH clinical trials.
基金：
National Natural Science Foundation of China
(82001389, 81901250, 81971222 and 81471340), the Natural Science Foundation of
Guangdong Province (2019A1515010104), and the High-level Hospital Construction Project
of Guangdong Provincial People’s Hospital (No.DFJH201924).
第一作者机构：[1]Department of Neurosurgery, Guangdong Provincial People's Hospital, GuangdongInstitute of Neuroscience, Guangdong Academy of Medical Sciences, Guangzhou,Guangdong 510080, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurosurgery, Guangdong Provincial People's Hospital, GuangdongInstitute of Neuroscience, Guangdong Academy of Medical Sciences, Guangzhou,Guangdong 510080, China[2]Institute of Cerebrovascular Disease Research and Department of Neurology, XuanwuHospital of Capital Medical University, Beijing 100053, China[7]Beijing Geriatric Medical Research Center and Beijing Key Laboratory of TranslationalMedicine for Cerebrovascular Diseases, Beijing 100053, China.[*1]Institute of Cerebrovascular Diseases Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China[*2]Department of Neurosurgery, Guangdong Provincial People's Hospital, Guangdong Institute of Neuroscience, Guangdong Academy of Medical Sciences, No. 106 Zhongshan 2nd Road, Yuexiu District, Guangzhou, Guangdong 510080, China
推荐引用方式(GB/T 7714)：
Chen Shengpan,Li Lingzhi,Peng Chao,et al.Targeting oxidative stress and inflammatory response for blood-brain barrier protection in intracerebral hemorrhage.[J].ANTIOXIDANTS & REDOX SIGNALING.2022,37(1-3):115-134.doi:10.1089/ars.2021.0072.
APA：
Chen Shengpan,Li Lingzhi,Peng Chao,Bian Chunjing,Eser Ocak Pinar...&Luo Yumin.(2022).Targeting oxidative stress and inflammatory response for blood-brain barrier protection in intracerebral hemorrhage..ANTIOXIDANTS & REDOX SIGNALING,37,(1-3)
MLA：
Chen Shengpan,et al."Targeting oxidative stress and inflammatory response for blood-brain barrier protection in intracerebral hemorrhage.".ANTIOXIDANTS & REDOX SIGNALING 37..1-3(2022):115-134
