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Mid-term effects of carotid endarterectomy on cognition and white matter status evaluated by whole brain diffusion tensor imaging metrics: A preliminary analysis.

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收录情况： ◇ SCIE

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机构： [1]Department of Radiology, AOU Cagliari, University of Cagliari, Italy [2]Stroke Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA, USA [3]Department of Radiology, IRCCS SDN, Italy [4]Department of Radiology (IDI) and Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain [5]Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, China [6]Department of Vascular Surgery, Central Clinic of Athens, Athens, Greece

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关键词： Carotid endarterectomy Asymptomatic carotid stenosis DTI Cognition MMSE

摘要：

To analyze the mid-term (12 months) effects of carotid endarterectomy (CEA) on cognition and on the microstructural properties of the whole brain white matter in terms of derived diffusion Tensor imaging (DTI) metrics.We analyzed a population of 19 asymptomatic patients with extra-cranial internal carotid artery stenosis (eICA) eligible for CEA. All patients underwent cognitive evaluation with the Italian version of the Mini-Mental State Examination corrected for age and schooling, and with a Magnetic Resonance Imaging (MRI) investigation on a 1.5 Tesla MRI scanner, that included a 34-directions Diffusion Weighted Imaging (DWI) sequence for DTI metrics analysis. The global fractional anisotropy (gFA), global mean diffusivity (gMD), global radial diffusivity (gRD) and global axial diffusivity (gAD) were calculated for each patient. Both the cognitive and the imaging evaluation were performed at baseline (PRE-CEA) and 12 months after CEA (POST-CEA). Two-tailed Paerson's correlation test and paired samples t-test were used for evaluating the correlation between PRE-CEA and POST-CEA values, adopting a p-value of <0.05 as statistically significant.A statistically significant increase of the MMSE scores (p < 0.0001), as well as for gFA (p < 0.0001), and a statistically significant reduction of gMD (p = 0.027) and gRD (p = 0.0005) was observed 12 months following uncomplicated CEA.These findings suggest that CEA is associated with a general improvement of the WM microstructure of the whole brain.Copyright © 2022 Elsevier B.V. All rights reserved.

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出版当年[2021]版：

大类 | 2 区医学

小类 | 3 区核医学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区核医学

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出版当年[2020]版：

Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

最新[2023]版：

Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 3.2 最新[2023版] 3.4 最新五年平均 3.528 出版当年[2020版] 3.539 出版当年五年平均 2.687 出版前一年[2019版] 4.531 出版后一年[2021版]

第一作者：

第一作者机构： [1]Department of Radiology, AOU Cagliari, University of Cagliari, Italy [*1]Department of Medical Imaging, Azienda Ospedaliera Universitaria di Cagliari, S.S: 554, km 4,500, CAP 09042 Monserrato, Cagliari, Italy

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通讯作者：

通讯机构： [1]Department of Radiology, AOU Cagliari, University of Cagliari, Italy [*1]Department of Medical Imaging, Azienda Ospedaliera Universitaria di Cagliari, S.S: 554, km 4,500, CAP 09042 Monserrato, Cagliari, Italy

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