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Mortality of myasthenia gravis: a national population-based study in China

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机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. [2]National Center for Neurological Disorders, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. [3]Department of Neurology, PLA Rocket Force Characteristic Medical Center, No. 16 Xinjiekouwai Street, Xicheng District, Beijing, 100088, China. [4]National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, No. 27 Nanwei Road, Xicheng District, Beijing, 100050, China. [5]Beijing Municipal Geriatric Medical Research Center, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China.

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As a potentially life-threatening condition, myasthenia gravis (MG) has limited epidemiological studies on mortality. We aim to provide demographic distribution, geographical variation, and temporal trend of MG-related mortality in China.The national population-based analysis was conducted based on records derived from the National Mortality Surveillance System of China. All deaths related to MG were identified from 2013 to 2020, and MG-related mortality was evaluated by sex, age, location, and year.A total of 4224 deaths were related to MG during 2013-2020, and the median age at death of MG was 59.45 years, significantly lower than that in the general population (75.47 years, P < 0.05). In 2020, the age-standardized mortality rate of MG was 1.86 per million people and markedly higher in males than in females (2.37 vs. 1.31 per million). The mortality rate per million was lower than 1 in young children, peaking at 2.83 only in males (vs. 0.36 in females) aged 10-19 years, and substantially increased with age, reaching the highest rate of 13.31 for males and 10.58 for females aged 80 years and older. Geographical disparity across China was observed with the highest age-standardized mortality rate in Southwest (2.53 per million). From 2013 to 2020, MG-related mortality rate showed an increasing trend with the average annual percentage change of 3.5% (95% CI, 1.4-5.6). The notable increases occurred in age 10-19 years and over 70 years.In China, MG-related mortality was notably high among adolescent males and the elderly. The increasing death burden due to MG highlight challenges to disease management.© 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

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出版当年[2022]版：

大类 | 2 区医学

小类 | 2 区临床神经病学 2 区神经科学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区临床神经病学 2 区神经科学

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出版当年[2021]版：

Q1 CLINICAL NEUROLOGY Q2 NEUROSCIENCES

最新[2024]版：

Q1 CLINICAL NEUROLOGY Q2 NEUROSCIENCES

影响因子： 3.9 最新[2024版] 4.3 最新五年平均 5.43 出版当年[2021版] 5.647 出版当年五年平均 4.511 出版前一年[2020版] 5.3 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. [2]National Center for Neurological Disorders, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. [3]Department of Neurology, PLA Rocket Force Characteristic Medical Center, No. 16 Xinjiekouwai Street, Xicheng District, Beijing, 100088, China.

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通讯作者：

通讯机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. [2]National Center for Neurological Disorders, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. [4]National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, No. 27 Nanwei Road, Xicheng District, Beijing, 100050, China. [5]Beijing Municipal Geriatric Medical Research Center, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. [*1]National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, No. 27 Nanwei Road, Xicheng District, Beijing 100050, China [*2]Department of Neurology, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.

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