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Structural changes in the thalamus and its subregions in regulating different symptoms of posttraumatic stress disorder

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Yang Beining[1,2] * ; Jia Yulong[1,2] ; Zheng Weimin[1,2] ; Wang Ling[1,2] ; Qi Qunya[1,2] ; Qin Wen[3] ; Li Xuejing[5] ; Chen Xin[1,2] ; Lu Jie[1,2] ; Li Huabing[4,*1] ; Zhang Quan[3,*2] ; Chen Nan[1,2,*3] ;
机构： [1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, 100053 Beijing, China [2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, 100053 Beijing, China [3]Department of Radiology, Tianjin Medical University General Hospital, 300052 Tianjin, China [4]Department of Radiology, Jinmei Group General Hospital, Jincheng 048006, Shanxi, China [5]Department of Radiology, China Rehabilitation Research Center, 100068 Beijing, China
出处：
DOI： 10.1016/j.pscychresns.2023.111706
ISSN：

关键词： Posttraumatic Thalamic subregion Gray matter volume Voxel-based morphometry Magnetic resonance imaging

摘要：
As a key center for sensory information processing and transmission, the thalamus plays a crucial role in the development of posttraumatic stress disorder (PTSD). However, the changes in the thalamus and its role in regulating different PTSD symptoms remain unclear. In this study, fourteen PTSD patients and eighteen healthy controls (HCs) were recruited. All subjects underwent whole-brain T1-weighted three-dimensional Magnetization Prepared Rapid Gradient Echo Imaging scans. Gray matter volume (GMV) in the thalamus and its subregions were estimated using voxel-based morphometry (VBM). Compared to HCs, PTSD patients exhibited significant GMV reduction in the left thalamus and its subregions, including anterior, mediodorsal, ventral-lateral-dorsal (VLD), ventral-anterior, and ventral-lateral-ventral (VLV). Among the significantly reduced thalamic subregions, we found positive correlations between the GMV values of the left VLD and VLV and the re-experiencing symptoms score, arousal symptoms score, and total CAPS score. When using the symptom-related GMV values of left VLV and VLD in combination as a predictor, receiver operating characteristic (ROC) analysis revealed that the area under the curve (AUC) for binary classification reached 0.813. This study highlights the neurobiological mechanisms of PTSD related to thalamic changes and may provide potential imaging markers for diagnosis and therapy targets.Copyright © 2023 Elsevier B.V. All rights reserved.

基金：
National Defense Science and Technology Special Zone Innovation Project (Contract Number:21–163–00-TS-018–007–01).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 精神病学 4 区 神经成像
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 神经成像 4 区 精神病学
JCR分区：
出版当年[2021]版：
Q3 CLINICAL NEUROLOGY Q3 NEUROIMAGING Q4 PSYCHIATRY
最新[2024]版：
Q3 CLINICAL NEUROLOGY Q3 NEUROIMAGING Q3 PSYCHIATRY

影响因子： 最新[2024版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, 100053 Beijing, China [2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, 100053 Beijing, China
通讯作者：
通讯机构： [1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, 100053 Beijing, China [2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, 100053 Beijing, China [3]Department of Radiology, Tianjin Medical University General Hospital, 300052 Tianjin, China [4]Department of Radiology, Jinmei Group General Hospital, Jincheng 048006, Shanxi, China [*1]Department of Radiology, Jinmei Group General Hospital, Beishidian Town, Jincheng City, China. [*2]Department of Radiology, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin, China. [*3]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, No. 45 Chang-Chun St, Xicheng District, Beijing, China.
推荐引用方式(GB/T 7714)：
Yang Beining,Jia Yulong,Zheng Weimin,et al.Structural changes in the thalamus and its subregions in regulating different symptoms of posttraumatic stress disorder[J].PSYCHIATRY RESEARCH-NEUROIMAGING.2023,335:doi:10.1016/j.pscychresns.2023.111706.
APA：
Yang Beining,Jia Yulong,Zheng Weimin,Wang Ling,Qi Qunya...&Chen Nan.(2023).Structural changes in the thalamus and its subregions in regulating different symptoms of posttraumatic stress disorder.PSYCHIATRY RESEARCH-NEUROIMAGING,335,
MLA：
Yang Beining,et al."Structural changes in the thalamus and its subregions in regulating different symptoms of posttraumatic stress disorder".PSYCHIATRY RESEARCH-NEUROIMAGING 335.(2023)

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