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Inflammaging score as a potential prognostic tool for cancer: A population-based cohort study

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收录情况： ◇ SCIE

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机构： [1]Department of Gastrointestinal Gland Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China [2]Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China [3]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China [4]Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, China [5]Laboratory for Clinical Medicine，Capital Medical University, Beijing, China

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关键词： Inflammaging score Cancer Prognosis Ageing Inflammatory status

摘要：

This study aimed to develop a clinically applicable inflammaging score by combining the inflammatory status and age of patients. Kaplan-Meier analysis was used to compare survival differences among patients with different grades of inflammation scores. Cox proportional hazard regression analysis was used to explore the relationship between the inflammaging score and survival. As the age of patients increased, their levels of systemic inflammation gradually increased. A unique inverse relationship was found between the level of inflammation and cancer prognosis during the ageing process. Mediation analysis indicated that systemic inflammation mediates 10.1%-17.8% of the association between ageing and poor prognosis. With an increase in the inflammaging score from grades I to V, the survival rate showed a gradient decline. The inflammation score could effectively stratify the prognosis of patients with lung, bronchial, gastrointestinal, and other types of cancers. Compared with grade I, the hazard ratios for grades II-V were 1.239, 1.604, 1.724, and 2.348, respectively. In the external validation cohort, the inflammaging score remained an independent factor affecting the prognosis of patients with cancer. The inflammaging score, which combines ageing and inflammation, is a robust prognostic assessment tool for cancer patients.Copyright © 2024 Elsevier B.V. All rights reserved.

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中科院(CAS)分区：

出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区细胞生物学 3 区老年医学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区老年医学 3 区细胞生物学

JCR分区：

出版当年[2022]版：

Q2 CELL BIOLOGY Q2 GERIATRICS & GERONTOLOGY

最新[2024]版：

Q1 GERIATRICS & GERONTOLOGY Q2 CELL BIOLOGY

影响因子： 5.1 最新[2024版] 5.9 最新五年平均 5.3 出版当年[2022版] 5.2 出版当年五年平均 5.498 出版前一年[2021版] 5.3 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Gastrointestinal Gland Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China [2]Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China [3]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China [4]Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, China [5]Laboratory for Clinical Medicine，Capital Medical University, Beijing, China

共同第一作者：

通讯作者：

通讯机构： [1]Department of Gastrointestinal Gland Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China [2]Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China [3]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China [4]Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, China [5]Laboratory for Clinical Medicine，Capital Medical University, Beijing, China

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Inflammaging score as a potential prognostic tool for cancer: A population-based cohort study

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