机构：[1]Capital Med Univ, Beijing Inst Brain Disorders, Beijing Adv Innovat Ctr Big Data Based Precis Med,, Collaborat Innovat Ctr Brain Disorders,Lab Brain D, Beijing 100069, Peoples R China[2]Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China[3]Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China首都医科大学宣武医院
The phenomenon of endothelial-mesenchymal transition (EndMT), a distinct subtype of epithelial-mesenchymal transition (EMT), has garnered significant attention from scholars. EndMT refers to the process whereby endothelial cells (ECs) transform into mesenchymal cells in response to various stimuli, resulting in the loss of their original characteristics. This process has diverse implications in both physiological and pathological states. Under physiological conditions, EndMT plays a crucial role in the development of the cardiovascular system. Conversely, under pathological conditions, EndMT has been identified as a pivotal factor in the development of cardiovascular diseases. Nonetheless, a comprehensive overview of EndMT in cerebrovascular disease is currently lacking. Here, we discuss the heterogeneity of EndMT occurrence and the regulatory factors involved in its development and analyze the feasibility of EndMT as a therapeutic target, aiming to provide a solid theoretical foundation and evidence to address diseases caused by pathological EndMT.
第一作者机构：[1]Capital Med Univ, Beijing Inst Brain Disorders, Beijing Adv Innovat Ctr Big Data Based Precis Med,, Collaborat Innovat Ctr Brain Disorders,Lab Brain D, Beijing 100069, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Inst Brain Disorders, Beijing Adv Innovat Ctr Big Data Based Precis Med,, Collaborat Innovat Ctr Brain Disorders,Lab Brain D, Beijing 100069, Peoples R China[3]Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
Jiang Huimin,Zhou Yifan,Zhang Weiyue,et al.Molecular mechanisms of endothelial-mesenchymal transition and its pathophysiological feature in cerebrovascular disease[J].CELL AND BIOSCIENCE.2025,15(1):doi:10.1186/s13578-025-01393-y.
APA：
Jiang, Huimin,Zhou, Yifan,Zhang, Weiyue,Li, Hui,Ma, Wei...&Zhou, Chen.(2025).Molecular mechanisms of endothelial-mesenchymal transition and its pathophysiological feature in cerebrovascular disease.CELL AND BIOSCIENCE,15,(1)
MLA：
Jiang, Huimin,et al."Molecular mechanisms of endothelial-mesenchymal transition and its pathophysiological feature in cerebrovascular disease".CELL AND BIOSCIENCE 15..1(2025)
生物学