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Mediation of Multiphase Collateral Status on Functional Outcome by ASPECTS-Based Net Water Uptake in Acute Stroke

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收录情况： ◇ SCIE

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机构： [1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China [3]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [4]China International Neuroscience Institute (China-INI), Beijing, China [5]Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China [6]Neuroendovascular Program, Massachusetts General Hospital & Brigham andWomen’s Hospital, Harvard Medical School, Boston, Massachusetts, USA [7]Departments of Medical Imaging & Clinical Neurological Sciences, Neurointerventional Program, London Health Sciences Centre,Western University, London, Ontario, Canada [8]Department of Interventional Neuroradiology, Xuanwu Hospital, Capital Medical University, Beijing, China

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关键词： acute ischemic stroke collateral status functional outcome mechanical thrombectomy net water uptake

摘要：

The Alberta Stroke Program Early CT Score-based net water uptake (ASPECTS-NWU) is a quantitative imaging biomarker used to assess early ischemic changes in acute ischemic stroke patients. ASPECTS-NWU has been investigated in identifying stroke onset time, measuring ischemic tissue edema, and predicting functional outcomes. However, the mediating effect of ASPECTS-NWU and its association with collaterals, infarct volume, and functional outcome still need to be explored. Therefore, we hypothesized that ASPECTS-NWU is a mediator between collateral circulation and infarct volume and investigated their association with outcome.There were 201 patients, and 131 of them underwent mechanical thrombectomy. Collaterals were graded using the multiphase Menon score. The mediating effect of ASPECTS-NWU between collaterals and infarct volume was investigated. The association between infarct volume, collaterals, recanalization status, and functional outcome was assessed by univariable and multivariate logistic regression analysis.Patients with good collaterals displayed higher ASPECTS, lower ASPECTS-NWU, lower National Institute of Health Stroke Scale score at admission (NIHSSadmission), and smaller infarct volume, ischemic tissue volume, and penumbra volume. ASPECTS-NWU was a mediator between collaterals and infarct volume, and the contribution rate of the mediator was 27.9%. In multivariate logistic regression analysis, infarct volume and recanalization status were associated with functional outcomes.ASPECTS-NWU was a mediator and played a partial role between collaterals and infarct volume. Infarct volume and recanalization status were strong predictors of functional outcome. ASPECTS-NWU and collaterals indirectly influenced functional outcomes by regulating infarct volume.© 2025 American Society of Neuroimaging.

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出版当年[2025]版：

大类 | 3 区医学

小类 | 3 区核医学 4 区临床神经病学 4 区神经成像

最新[2025]版：

大类 | 3 区医学

小类 | 3 区核医学 4 区临床神经病学 4 区神经成像

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出版当年[2023]版：

Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q3 CLINICAL NEUROLOGY Q3 NEUROIMAGING

最新[2024]版：

Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q3 CLINICAL NEUROLOGY Q3 NEUROIMAGING

影响因子： 2.3 最新[2024版] 2.3 最新五年平均 2.3 出版当年[2023版] 2.3 出版当年五年平均 2.4 出版前一年[2022版] 2.3 出版后一年[2024版]

第一作者：

第一作者机构： [1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China

通讯作者：

通讯机构： [1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China

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Mediation of Multiphase Collateral Status on Functional Outcome by ASPECTS-Based Net Water Uptake in Acute Stroke

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