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Origin, functions, heterogeneity and associated diseases of B-1 cells

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机构： [1]Department of Immunology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men, Beijing 100069, PR China [2]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China [3]Beijing Shijitan Hospital, Capital Medical University, No. 10 Yangfangdian Street, Tieyi Road, Haidian District, Beijing 100038, China [4]Faculty of Life Sciences & Medicine, School of Immunology & Microbial Sciences, King’s College London, London, UK

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关键词： B-1 cells Lineage model Differentiation model Natural antibodies Heterogeneity B-1 associated diseases

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B-1 cells are derived from a subpopulation of B lymphocytes which have a specific developmental process, unique phenotype and location, and distinct functions in comparison with conventional B-2 cells. The origin of B-1 cells is not completely clear, with two existing hypotheses concerning their lineage and differentiation pathways. B-1 cells are located principally in the peritoneal and pleural cavities, but are also distributed in secondary lymphoid tissues, at mucosal sites and in the blood and bone marrow. B-1 cells regulate immune responses and maintain homeostasis by secretion of natural antibodies (nAbs), and participate in the adaptive immune response through phagocytosis and presentation of antigens to T cells. B-1 cells are associated with many diseases including autoimmune, infectious and inflammatory diseases. This review focuses on the origin and biological functions of B-1 cells as well as their involvement in human disease, and discusses advances in the understanding of the heterogeneity of B-1 cells under specific pathophysiological features, as partly clarified by single-cell sequencing analysis.Copyright © 2025. Published by Elsevier Inc.

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出版当年[2025]版：

大类 | 3 区医学

小类 | 3 区免疫学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区免疫学

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出版当年[2023]版：

Q2 IMMUNOLOGY

最新[2024]版：

Q2 IMMUNOLOGY

影响因子： 3.8 最新[2024版] 4.3 最新五年平均 4.5 出版当年[2023版] 4.7 出版当年五年平均 8.6 出版前一年[2022版] 3.8 出版后一年[2024版]

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第一作者机构： [1]Department of Immunology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men, Beijing 100069, PR China

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