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Generation of patient-derived sarcoma organoids for personalized drug screening and precision cancer immunotherapy

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收录情况： ◇ SCIE

作者：
Ma Haixia[1,2] * ; Li Xiaoyang[3] * ; Li Jinxi[4] * ; Bu Jie[5] * ; Li Xianan[5] * ; Zhang Jie[1] ; Yu Shengji[3] ; Nie Guangjun[1,6] ; Wang Hai[1,6] ; Feng Helin[3] ;
机构： [1]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China [2]Department of Clinical Laboratory, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, Beijing, 100053, China [3]Department of Orthopedics, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China [4]State Key Laboratory of Genetics and Development of Complex Phenotypes, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, and Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Fudan University, Shanghai, China [5]Department of Orthopedics and Soft Tissue, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China [6]University of Chinese Academy of Sciences, Beijing, 100049, China
出处：
DOI： 10.1016/j.biomaterials.2025.123546
ISSN：

关键词： Organoids Sarcoma Drug screen Precision cancer immunotherapy

摘要：
Sarcomas are malignant tumors that display inter- and intra-tumoral heterogeneity. Patient-derived organoids enable the creation of systems that stably recapitulate many aspects of parental tumors in vitro. Thus, the idea of using patient-derived organoids for therapeutic screening and precision medicine is tantalizing. Here, we describe a biobank of soft tissue and bone sarcoma (STBS) organoid lines derived from patient tumor tissues. In total, we established 44 STBS organoid lines, representing eight subtypes of STBS. These STBS organoids faithfully recapitulate the histological features, mutational profiles, gene expression profiles, and cellular diversity of the corresponding tumors. STBS organoids can be used not only for screening chemotherapeutic and target therapeutic drugs, but also for predicting immune responses. Our data demonstrate the potential of STBS organoids for both basic research and for designing personalized sarcoma treatments.Copyright © 2025 Elsevier Ltd. All rights reserved.

基金：
The authors thank the participants for donating their tissues for this study. This work was supported by the China Postdoctoral Science Foundation (NO.2020M670244), NSFC (31971307, 82272964), and the Start-up Foundation of National Center for Nanoscience and Technology
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外文
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出版当年[2025]版：
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大类 | 1 区 医学
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
JCR分区：
出版当年[2024]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS
最新[2024]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 最新[2024版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China [2]Department of Clinical Laboratory, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, Beijing, 100053, China
共同第一作者：
通讯作者：
通讯机构： [1]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China [6]University of Chinese Academy of Sciences, Beijing, 100049, China
推荐引用方式(GB/T 7714)：
Ma Haixia,Li Xiaoyang,Li Jinxi,et al.Generation of patient-derived sarcoma organoids for personalized drug screening and precision cancer immunotherapy[J].Biomaterials.2026,324:123546.doi:10.1016/j.biomaterials.2025.123546.
APA：
Ma Haixia,Li Xiaoyang,Li Jinxi,Bu Jie,Li Xianan...&Feng Helin.(2026).Generation of patient-derived sarcoma organoids for personalized drug screening and precision cancer immunotherapy.Biomaterials,324,
MLA：
Ma Haixia,et al."Generation of patient-derived sarcoma organoids for personalized drug screening and precision cancer immunotherapy".Biomaterials 324.(2026):123546

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