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A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium

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机构: [1]Capital Med Univ, Beijing Key Lab Ophthalmol & Visual Sci, Beijing Tongren Hosp, Beijing Tongren Eye Ctr,Beijing Inst Opthalmol, Beijing 100005, Peoples R China [2]Capital Med Univ, Sch Basic Med Sci, Beijing 100069, Peoples R China [3]Sun Yat Sen Univ, Guangdong Prov Clin Res Ctr Ocular Dis, Guangdong Prov Key Lab Ophthalmol & Vis Sci, State Key Lab Ophthalmol,Zhongshan Ophthalm Ctr, Guangzhou 510060, Peoples R China [4]Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Natl Clin Res Ctr Geriatr Disorders, Aging Translat Med Ctr,Xuanwu Hosp, Beijing 100053, Peoples R China [5]Chinese Acad Sci, China Natl Ctr Bioinformat, Beijing 100101, Peoples R China [6]Chinese Acad Sci, Beijing Inst Genom, Beijing 100101, Peoples R China [7]Chinese Acad Sci, Beijing Inst Genom, Beijing 101408, Peoples R China [8]Chinese Acad Sci, Inst Zool, State Key Lab Organ Regenerat & Reconstruct, Beijing 100101, Peoples R China [9]Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China [10]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing 100029, Peoples R China [11]Univ Chinese Acad Sci, Beijing 100049, Peoples R China [12]Peking Univ First Hosp, Dept Ophthalmol, Beijing 100034, Peoples R China [13]Univ Sci & Technol China, Affiliated Hosp 1, Dept Ophthalmol, Hefei 230001, Peoples R China [14]Shanghai Jiao Tong Univ, State Key Lab Visual Sci, Dept Ophthalmol, Sch Med,Shanghai Peoples Hosp 9, Shanghai 200011, Peoples R China [15]Capital Med Univ, Xuanwu Hosp, Dept Ophthalmol, Beijing 100037, Peoples R China [16]Peoples Hosp Ningxia Hui Autonomous Reg, Dept Ophthalmol, Yinchuan 750011, Peoples R China [17]Fudan Univ, Eye & ENT Hosp, Dept Opthalmol, Shanghai 200031, Peoples R China [18]Sci & Technol Commiss Shanghai Municipal, Shanghai Key Lab Visual Impairment & Restorat, Shanghai 200031, Peoples R China [19]NHC, Key Lab Myopia & Related Eye Dis, Shanghai 200031, Peoples R China [20]Chinese Acad Med Sci, Key Lab Myopia & Related Eye Dis, Shanghai 200031, Peoples R China [21]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing 100005, Peoples R China [22]Fudan Univ, Eye & ENT Hosp, State Key Lab Med Neurobiol, Dept Ophthalmol, Shanghai 200031, Peoples R China [23]Fudan Univ, MOE Frontiers Ctr Brain Sci, Shanghai 200031, Peoples R China [24]Southern Med Univ, Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Eye Inst,Dept Opthalmol, Guangzhou 510080, Peoples R China [25]Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Dept Ophthalmol, Shanghai 200080, Peoples R China [26]Hong Kong Polytech Univ, Hong Kong 999077, Peoples R China [27]Univ Chinese Acad Sci, Eye Hosp, State Key Lab Ophthalmol Optometry & Visual Sci, Wenzhou Inst,Wenzhou Med Univ, Wenzhou 325041, Peoples R China [28]Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325001, Peoples R China [29]Tongji Univ, Tongji Hosp, Collaborat Innovat Ctr Brain Sci, Sch Life Sci & Technol, Shanghai 200092, Peoples R China [30]Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R China [31]Univ Sci & Technol China, Affiliated Hosp USTC 1, Sch Life Sci,,Dept Ophthalmol, State Key Lab Eye Hlth,Div Life Sci & Med, Hefei 230026, Peoples R China
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摘要:
The visual system is essential for human perception, converting light signals into electrical impulses and transmitting them to the brain to process environmental information. As individuals age, their physiological functions gradually decline, leading to age-related vision impairment that significantly impacts the quality of life in elderly individuals. China is home to the world's largest aging population and faces significant challenges in combating visual system aging through effective treatments and interventions. In response to this challenge, the Aging Biomarker Consortium (ABC) of China has developed a consensus statement on biomarkers of visual system aging by integrating cutting-edge global research and synthesizing evidence-based medicine with clinical expertise. This consensus provides a multi-dimensional evaluation framework encompassing functional, morphological, and molecular biomarkers. Validated biomarkers for each domain are recommended not only to facilitate the early detection of vision changes but also to provide insights into the progression of age-related ocular diseases. By advancing this initiative, ABC aims to revolutionize visual health management in aging societies, ultimately improving outcomes for elderly populations in China and globally.

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大类 | 4 区 医学
小类 | 4 区 医学:研究与实验
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大类 | 4 区 医学
小类 | 4 区 医学:研究与实验
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Q1 MEDICINE, RESEARCH & EXPERIMENTAL

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第一作者机构: [1]Capital Med Univ, Beijing Key Lab Ophthalmol & Visual Sci, Beijing Tongren Hosp, Beijing Tongren Eye Ctr,Beijing Inst Opthalmol, Beijing 100005, Peoples R China
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通讯作者:
通讯机构: [5]Chinese Acad Sci, China Natl Ctr Bioinformat, Beijing 100101, Peoples R China [6]Chinese Acad Sci, Beijing Inst Genom, Beijing 100101, Peoples R China [7]Chinese Acad Sci, Beijing Inst Genom, Beijing 101408, Peoples R China [8]Chinese Acad Sci, Inst Zool, State Key Lab Organ Regenerat & Reconstruct, Beijing 100101, Peoples R China [9]Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China [10]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing 100029, Peoples R China [11]Univ Chinese Acad Sci, Beijing 100049, Peoples R China [17]Fudan Univ, Eye & ENT Hosp, Dept Opthalmol, Shanghai 200031, Peoples R China [18]Sci & Technol Commiss Shanghai Municipal, Shanghai Key Lab Visual Impairment & Restorat, Shanghai 200031, Peoples R China [19]NHC, Key Lab Myopia & Related Eye Dis, Shanghai 200031, Peoples R China [20]Chinese Acad Med Sci, Key Lab Myopia & Related Eye Dis, Shanghai 200031, Peoples R China [22]Fudan Univ, Eye & ENT Hosp, State Key Lab Med Neurobiol, Dept Ophthalmol, Shanghai 200031, Peoples R China [23]Fudan Univ, MOE Frontiers Ctr Brain Sci, Shanghai 200031, Peoples R China [27]Univ Chinese Acad Sci, Eye Hosp, State Key Lab Ophthalmol Optometry & Visual Sci, Wenzhou Inst,Wenzhou Med Univ, Wenzhou 325041, Peoples R China [28]Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325001, Peoples R China
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