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Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia-specific perspectives

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机构: [1]Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. [2]Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. [3]Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. [4]National Center for Geriatrics and Gerontology, Obu, Japan. [5]Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore. [6]Mallinckrodt Institute of Radiology, Neuroradiology Section, Washington University, St. Louis, Missouri, USA. [7]Medical Scientific Relations, Alzheimer's Association, Chicago, Illinois, USA. [8]Department of Pharmacology, Memory Aging and Cognition Centre, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. [9]Department of Neurology, Inha University College of Medicine, Incheon, Republic of Korea. [10]Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA. [11]Departments of Psychiatry Human Behavior and Neurobiology Behavior, Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, USA. [12]Michigan Alzheimer's Disease Research Center and Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA. [13]Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. [14]Department of Neurology, Dementia Center, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan. [15]Department of Neurology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan. [16]Department of Molecular Genetics, Brain Research Institute, Niigata, Japan. [17]State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, The Hong Kong University of Science and Technology Hong Kong Center For Neurodegenerative Diseases, Hong Kong SAR, China. [18]Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia. [19]Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA. [20]Department of Neurology, Ewha Womans University College of Medicine, Seoul, Republic of Korea. [21]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. [22]Dementia Research Centre (Singapore) Neuroscience and Mental Health Programme, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. [23]National Healthcare Group, Singapore, Singapore. [24]Department of Neurology, Seoul National University College of Medicine Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. [25]Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan. [26]Department of Neurology, Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California, San Francisco (UCSF), San Francisco, California, USA. [27]Unit for Early and Exploratory Clinical Development, University of Tokyo Hospital, Tokyo, Japan. [28]Health and Global Policy Institute, Otemachi, Tokyo, Japan. [29]Okayama University, Kita Ward, Okayama, Japan. [30]Department of Medicine and the Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. [31]Memory Clinic, Skåne University Hospital, Malmö, Sweden. [32]Department of Clinical Sciences, Clinical Memory Research Unit, Malmö, Lund University, Lund, Sweden. [33]Alzheimer's Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego, California, USA. [34]Neurodegenerative Disorder Research Center and Brain Bank, University of Science and Technology of China, Hefei, China. [35]Department of Neurology and the Institute on Aging and Brain Disorders, The First Affiliated Hospital, University of Science and Technology of China, Hefei, China. [36]Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. [37]Department of Internal Medicine, Division of Geriatric Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Nakhon Pathom, Thailand. [38]Division of Behavioral and Social Research, National Institute on Aging, Bethesda, Maryland, USA. [39]Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. [40]Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands. [41]Epidemiology and Data Science, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. [42]Dementia Care and Research Center, Peking University Institute of Mental Health (Sixth Hospital), Beijing Municipal Key Lab for Translational Research on Diagnosis and Treatment of Dementia, National Clinical Research Center for Mental Disorders, NHC Key Laboratory for Mental Health, Beijing, China. [43]Department of Neurology, Center for Neurodegenerative Disorders, IUSM/IUH Neuroscience Institute and Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA. [44]Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, M ölndal, Sweden. [45]Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M ölndal, Sweden. [46]Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK. [47]UK Dementia Research Institute at UCL, London, UK. [48]Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China. [49]Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA. [50]Clinical Development Neurology, Eisai Inc., Nutley, New Jersey, USA.
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关键词: Alzheimer’s disease Asia biomarker dementia diagnosis

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The landscape of Alzheimer's disease (AD) and related dementias (ADRD) diagnosis is evolving rapidly, driven by advances in disease understanding, biomarker tools, and disease-modifying therapies. Modern diagnostic approaches emphasize biological precision, early detection, and dynamic frameworks that adapt to treatment-induced changes in disease biology. These frameworks enable opportunities for personalized interventions-encompassing pharmacological and non-pharmacological strategies-and for enhanced clinical trial design. However, implementing these advancements globally is influenced by diverse cultural, infrastructural, and regulatory factors. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis, held in Japan, provided a unique platform to explore these global dynamics, particularly from an Asian perspective. This article highlights key discussions from the conference, exploring the role of biomarker-based diagnostic frameworks in shaping the future of AD/ADRD research, diagnosis, and treatment. We highlight regional challenges and successes and emphasize ethical considerations and practical strategies needed to ensure equitable access to diagnostic and therapeutic innovations. HIGHLIGHTS: Advances in biomarkers are reshaping Alzheimer's disease diagnosis and treatment. Modern diagnostic frameworks highlight biological precision, early detection, and dynamic frameworks. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis explored challenges and opportunities in global biomarker implementation. The conference explored geographic-specific impacts, focusing on Asia.© 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

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大类 | 1 区 医学
小类 | 1 区 临床神经病学
最新[2025]版:
大类 | 1 区 医学
小类 | 1 区 临床神经病学
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第一作者机构: [1]Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
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