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Distinct Inflammatory Profiles and Clinical Characteristics of NMOSD: A Comparative Analysis with NMOSD-like and Encephalitis-like MOG-AD

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机构： [1]Department of Neurology, The First Hospital of China Medical University, Shenyang 110001, Liaoning, China. [2]Department of Neurology, Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing 100053, China. [3]Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin 150081, Heilongjiang, China. [4]Department of Radiology, The First Hospital of China Medical University, Shenyang 110001, Liaoning, China. [5]Department of Cardiology, The First Hospital of China Medical University, Shenyang 110001, Liaoning, China.

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关键词： neuromyelitis optica spectrum disorder myelin oligodendrocyte glycoprotein antibody associated disease plasma proteomics biomarker

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To better differentiate neuromyelitis optica spectrum disorder (NMOSD) from myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), it is crucial to systematically explore the correlation between their clinical and immunological characteristics. Utilizing high-throughput protein detection technologies, we analyzed 92 inflammation-related proteins in plasma samples from NMOSD (n = 50), NMOSD-like MOGAD (n = 12), and encephalitis-like MOGAD (n = 8) groups. In this study, we found that seizures (2% vs 30%, p < 0.001) and acute disseminated encephalomyelitis (0% vs 30%, p < 0.001) were more common in MOGAD, while transverse myelitis (52% vs 5%, p < 0.001) was more common in NMOSD. The signs and symptoms of NMOSD-like and encephalitis-like MOGAD were largely similar. There were no significant differentially expressed proteins identified between the NMOSD group and the NMOSD-like MOGAD group, while the elevated IL-24 and TRANCE were in the encephalitis-like MOGAD group rather than in the NMOSD group. There was a positive correlation of CCL20 expression with EDSS scores in the NMOSD group, while this association was not found in the other groups. In conclusion, encephalitis-like MOGAD has distinct clinical and peripheral inflammatory protein characteristics compared to NMOSD and NMOSD-like MOGAD. Some differential IRPs are closely associated with specific clinical parameters.

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出版当年[2025]版：

大类 | 2 区生物学

小类 | 2 区生化研究方法

最新[2025]版：

大类 | 2 区生物学

小类 | 2 区生化研究方法

第一作者：

第一作者机构： [1]Department of Neurology, The First Hospital of China Medical University, Shenyang 110001, Liaoning, China. [2]Department of Neurology, Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing 100053, China.

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通讯作者：

通讯机构： [1]Department of Neurology, The First Hospital of China Medical University, Shenyang 110001, Liaoning, China. [2]Department of Neurology, Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing 100053, China.

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