机构：[1]Department of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.[2]State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Public Health, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China.[3]Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China.[4]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, China.神经科系统神经外科首都医科大学宣武医院[5]State Key Laboratory of Neurology and Oncology Drug Development, Nanjing 210000, China.[6]School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair & Beijing Laboratory of Oral Health, Capital Medical University, Beijing 100069, China.[7]Chinese Institute for Brain Research, Beijing 102206, China.[8]Department of Neurology, Aerospace Center Hospital, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.[9]Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.四川省人民医院[10]Institute for Stem Cell and Regeneration, Chinese Academy of Science, Beijing, China.[11]Southeast University Shenzhen Research Institute, Shenzhen 518063, China.
Peripheral nerve injury is challenging to self-repair and often leads to severe functional impairment. Utilizing neural tissue engineering scaffolds to promote nerve regeneration presents a promising strategy. However, current nerve scaffolds generally lack the ability to accurately replicate the viscoelastic properties of native neural tissues. Here, aligned carbon nanotubes (ACNTs) were integrated onto the surface of gelatin methacryloyl (GelMA) with a 30% MA substitution degree (GelMA30), exhibiting viscoelastic properties closest to those of neural tissue, to fabricate GelMA30-ACNT (GM30-ACNT) scaffolds. Subsequently, an additional outer layer of GelMA with a 90% MA substitution degree (GelMA90) was applied to construct GelMA30/90-ACNT (GM30/90-ACNT) nerve guidance conduits (NGCs), aiming to enhance the mechanical properties of the NGCs. The scaffolds exhibit viscoelastic properties close to those of nerve tissues while retaining the topological guidance cues and excellent conductivity of ACNTs. The results demonstrated that the prepared GM30/90-ACNT substrates supported the growth and differentiation of pheochromocytoma (PC12) in vitro and significantly promoted the oriented extension of neurites. Additionally, the NGCs based on the GM30/90-ACNT scaffold significantly facilitated nerve regeneration and motor function recovery in a rat sciatic nerve injury model. These findings suggest that viscoelastic and conductive scaffolds represent a promising alternative for peripheral nerve injury repair.
基金：
the National Key R&D
Program of China (No. 2021YFA1101300, 2021YFA1101800,
and 2020YFA0112503), the National Natural Science
Foundation of China (No. 82330033, 82030029, 81970882, and
92149304), the Shenzhen Fundamental Research Program (No.JCYJ20190814093401920, and JCYJ20210324125608022), the
Open Project Fund of Guangdong Academy of Medical
Sciences (YKY-KF202201), the Beijing Natural Science
Foundation (No. Z200019), the China National Postdoctoral
Program for Innovative Talent (No. BX20230070), the China
Postdoctoral Science Foundation (No. 2023M740606), the
Jiangsu Funding Program for Excellent Postdoctoral Talent
(No. 2023ZB597), and the SEU Innovation Capability
Enhancement Plan for Doctoral Students (CXJH_SEU 24214,
and CXJH_SEU 25213)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|3 区材料科学
小类|3 区化学：综合3 区材料科学：综合3 区纳米科技3 区物理：应用
最新[2025]版：
大类|3 区材料科学
小类|3 区化学：综合3 区材料科学：综合3 区纳米科技3 区物理：应用
第一作者：
第一作者机构：[1]Department of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.[2]State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Public Health, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China.[3]Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China.
共同第一作者：
通讯作者：
通讯机构：[2]State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Public Health, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China.[3]Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China.[5]State Key Laboratory of Neurology and Oncology Drug Development, Nanjing 210000, China.[6]School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair & Beijing Laboratory of Oral Health, Capital Medical University, Beijing 100069, China.[7]Chinese Institute for Brain Research, Beijing 102206, China.[8]Department of Neurology, Aerospace Center Hospital, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.[9]Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.[10]Institute for Stem Cell and Regeneration, Chinese Academy of Science, Beijing, China.[11]Southeast University Shenzhen Research Institute, Shenzhen 518063, China.
推荐引用方式(GB/T 7714)：
Yin Haiyan,Hu Yangnan,Cheng Hong,et al.Viscoelastic and conductive nerve guidance conduits for peripheral nerve repair[J].Nanoscale.2025,doi:10.1039/d5nr00742a.
APA：
Yin Haiyan,Hu Yangnan,Cheng Hong,Zhang Bin,Gao Shan...&Chai Renjie.(2025).Viscoelastic and conductive nerve guidance conduits for peripheral nerve repair.Nanoscale,,
MLA：
Yin Haiyan,et al."Viscoelastic and conductive nerve guidance conduits for peripheral nerve repair".Nanoscale .(2025)
