机构：[1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, China International Neuroscience Institute, National Center for Neurological Disorders, Beijing 100053, China.神经科系统神经外科首都医科大学宣武医院[2]National Institute of Biological Sciences, Beijing 102206, China.[3]Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 100084, China.
Accumulating evidence highlights the crucial role of the gut-brain axis in diseases. This bidirectional signaling connects the gastrointestinal tract (GI) and the brain via neural, immune, and endocrine pathways, orchestrating a range of physiological processes. Dysregulation of the gut-brain axis has been related to a variety of neuropsychiatric, neurodegenerative, and neurodevelopmental disorders, as well as to disturbances in emotional regulation, cognition, and feeding-related conditions. The complex molecular interactions underlying this axis are necessary for maintaining homeostasis and overall health. Emerging pharmacological interventions and therapeutic targets have demonstrated potential in modulating gut-brain signaling to influence disease outcomes. This review provides a comprehensive view of the gut-brain axis, detailing its pivotal role in disease pathogenesis and exploring its therapeutic relevance.
基金：
the National Natural Science Foundation of China (32100821 to J.C.).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|2 区医学
小类|2 区生理学
最新[2025]版：
大类|2 区医学
小类|2 区生理学
第一作者：
第一作者机构：[1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, China International Neuroscience Institute, National Center for Neurological Disorders, Beijing 100053, China.
通讯作者：
通讯机构：[2]National Institute of Biological Sciences, Beijing 102206, China.[3]Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 100084, China.
推荐引用方式(GB/T 7714)：
Chen Jing,Xu Yijia,Cao Peng.The role of the gut-brain axis in diseases[J].Physiology (Bethesda, Md.).2025,doi:10.1152/physiol.00016.2025.
APA：
Chen Jing,Xu Yijia&Cao Peng.(2025).The role of the gut-brain axis in diseases.Physiology (Bethesda, Md.),,
MLA：
Chen Jing,et al."The role of the gut-brain axis in diseases".Physiology (Bethesda, Md.) .(2025)
：