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Simultaneous tDCS-rTMS stimulation to regulate the language network and improve language ability in Landau-Kleffner syndrome

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Chen Runze[1,2,3] * ; Liu Xinyan[4,5,6] * ; Qi Xiaohong[1] ; Shen Wenwen[1] ; Leng Xuerong[1] ; Zhang Xiating[7] ; Zhang Liping[1] ; Zhang Yuexin[7] ; Zhao Xuan[1] ; Wang Xingyu[7] ; Zhang Jicong[4,5,6] ; Wang Yuping[2,3,7] ; Lin Yicong[2,3,7] ;
机构： [1]Department of Pediatrics, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]Beijing Key Laboratory of Neuromodulation, Beijing, China. [3]Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China. [4]School of Biological Science and Medical Engineering, Beihang University, Beijing, China. [5]Beijing Advanced Innovation Centre for Big Data-Based Precision Medicine, Beihang University, Beijing, China. [6]Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, China. [7]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
出处：
DOI： 10.1002/epi4.70114

关键词： Landau–Kleffner syndrome language regression magnetoencephalography simultaneous transcranial direct current stimulation and transcranial magnetic stimulation

摘要：
Landau-Kleffner syndrome (LKS) is a rare epileptic syndrome causing language regression. In this preliminary study, we investigated the effects of simultaneous transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (rTMS) on LKS patients and the underlying mechanism based on magnetoencephalography (MEG) network analysis. Three LKS patients were included, all receiving daily stimulation for 15 days in 3 weeks, with MEG data collected to determine stimulation target and measure functional connectivity through normalized phase transfer entropy (PTE). The primary clinical outcome was measured through the Peabody Picture Vocabulary Test. Two patients with clustered spike dipoles in the right inferior parietal lobe (IPL) showed profound clinical improvement after stimulation. PTE analysis showed increased dorsal pathway information flow, mainly in the left hemisphere, and increased ventral pathway information flow in both hemispheres. This study preliminarily showed that tDCS-rTMS was safe to undergo and likely to improve language function in LKS patients. Stimulating the right IPL not only affects the right hemisphere language network but also profoundly affects the left hemisphere network that participates in language perception, processing, and understanding. The dynamic balance of the language network connections was reconstructed, which may be associated with improved language function in LKS. PLAIN LANGUAGE SUMMARY: Due to the lack of effective long-term treatment options, we investigated the effects of transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (rTMS) on language function in Landau-Kleffner syndrome (LKS) patients and the possible therapeutic mechanism by magnetoencephalography network analysis. Three LKS patients were included. We found tDCS-rTMS improved language function without side effects in two of the patients whose stimulation target was the right inferior parietal lobe, possibly due to significantly enhanced information flow in bilateral language streams, indicating modulated language network connections. Thus, we preliminarily proved the safety and effectiveness of tDCS-rTMS and unveiled underlying network mechanisms.© 2025 The Author(s). Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.

基金：
Natural Science Foundation of Beijing Municipality, Grant/Award Number: Z200024; Beijing Hospital Authority Cultivation Project, Grant/ Award Number: PX2023032; National Support Provincial Major Disease Medical Services and Social Capability Enhancement Project
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 3 区 医学
小类 | 3 区 临床神经病学 3 区 神经科学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 临床神经病学 3 区 神经科学
JCR分区：
出版当年[2023]版：
Q2 CLINICAL NEUROLOGY Q2 NEUROSCIENCES
最新[2024]版：
Q2 CLINICAL NEUROLOGY Q2 NEUROSCIENCES

影响因子： 最新[2024版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版] 出版后一年[2024版]

第一作者：
第一作者机构： [1]Department of Pediatrics, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]Beijing Key Laboratory of Neuromodulation, Beijing, China. [3]Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
共同第一作者：
通讯作者：
通讯机构： [2]Beijing Key Laboratory of Neuromodulation, Beijing, China. [3]Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China. [4]School of Biological Science and Medical Engineering, Beihang University, Beijing, China. [5]Beijing Advanced Innovation Centre for Big Data-Based Precision Medicine, Beihang University, Beijing, China. [6]Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, China. [7]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
推荐引用方式(GB/T 7714)：
Chen Runze,Liu Xinyan,Qi Xiaohong,et al.Simultaneous tDCS-rTMS stimulation to regulate the language network and improve language ability in Landau-Kleffner syndrome[J].Epilepsia Open.2025,doi:10.1002/epi4.70114.
APA：
Chen Runze,Liu Xinyan,Qi Xiaohong,Shen Wenwen,Leng Xuerong...&Lin Yicong.(2025).Simultaneous tDCS-rTMS stimulation to regulate the language network and improve language ability in Landau-Kleffner syndrome.Epilepsia Open,,
MLA：
Chen Runze,et al."Simultaneous tDCS-rTMS stimulation to regulate the language network and improve language ability in Landau-Kleffner syndrome".Epilepsia Open .(2025)

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