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Vitamin C conveys geroprotection on primate ovaries

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收录情况： ◇ 自然指数

作者：
Ying Jing[1] * ; Huifen Lu[1] * ; Jingyi Li[2,3,4,14] * ; Zan He[1] ; Liyun Zhao[1] ; Chen Zhang[10] ; Ziqi Huang[1] ; Lixiao Liu[3,5] ; Shuhui Sun[7] ; Shuai Ma[2,3,4,14] ; Concepcion Rodriguez Esteban[11] ; Xiaobing Fu[9] ; Guoguang Zhao[8] ; Juan Carlos Izpisua Belmonte[11,12] ; Weiqi Zhang[3,5,6,14] ; Jing Qu[2,3,4,7,13,14] ; Si Wang[1,14] ; Guang-Hui Liu[2,3,4,13,14] ;
机构： [1]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Aging TranslationalMedicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu HospitalCapital Medical University, Beijing 100053, China [2]State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]University of Chinese Academy of Sciences, Beijing 100049, China [4]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [5]China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China [6]Sino-Danish College, University of Chinese Academy of Sciences, Sino-Danish Center for Education and Research, Beijing 101408, China [7]Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China [8]Department of Neurosurgery, Beijing Municipal Geriatric Medical Research Center, National Medical Center for Neurological Diseases,Xuanwu Hospital Capital Medical University, Beijing 100053, China [9]Key Laboratory of Tissue Repair and Regeneration of PLA, Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, MedicalInnovation Department, PLA General Hospital and PLA Medical College, Beijing 100853, China [10]The Fifth People’s Hospital of Chongqing, Chongqing 400062, China [11]Altos Labs San Diego Institute of Science, San Diego, CA, USA [12]Salk Institute for Biological Studies, La Jolla, CA 92037, USA [13]Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [14]Aging Biomarker Consortium (ABC), Beijing 100101, China
出处：
DOI： 10.1016/j.stem.2025.09.008
ISSN：

摘要：
Ovarian aging plays a pivotal role in female reproductive health, with implications for treatment strategies and quality of life. However, the potential of a single pharmaceutical agent to mitigate primate ovarian aging remains largely unexplored. Our 3.3-year study in monkeys demonstrates that oral vitamin C has geroprotective effects against ovarian aging. Vitamin C diminishes key aging biomarkers, including oxidative stress and follicular depletion. Using a single-cell transcriptomic clock, we show that vitamin C can reduce the biological age of oocytes by 1.35 years and somatic cells by 5.66 years. This effect is partly mediated by the NRF2 pathway, which alleviates ovarian cell senescence and inflammation. Our findings highlight the role of vitamin C in combating primate ovarian aging and provide insights for developing interventions against human ovarian aging.Copyright © 2025 Elsevier Inc. All rights reserved.

基金：
This work was supported by the National Natural Science Foundation of China (82488301, 82125011, and 32400968), the National Key Research and Development Program of China (2024YFC2706600, 2020YFA0804000, and 2022YFA1103700), the STI2030-Major Projects (2021ZD0202400, 2023YFC3504301, and 2022YFA1103800), the National Natural Science Foundation of China (92168201, 82330044, 32341001, 82361148131, 82422031, 82322025, 82361148130, 8231101626, 82471586, 92468303, 82471594, 32121001, 82192863, 82471594, 82571781, and 82271600), the Non-Communicable Chronic Diseases-National Science and Technology MajorProject (2024ZD0530400), theProgram oftheBeijing Natural Science Foundation (Z240018, F251011, Z230011, and JQ24044), the CAS Project for Young Scientists in Basic Research (YSBR-076, YSBR-012, and YSBR-036), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA0460403 and XDC0200000), the Shenzhen Medical Research Fund (C2406001), the Beijing Anzhen Hospital High Level Research Funding (2024AZB3002), the Informatization Plan of Chinese Academy of Sciences (CAS-WX2022SDC-XK14), the New Cornerstone Science Foundation through the XPLORER PRIZE (2021-1045), the Beijing Nova Program (20240484493), the Key Laboratory of Alzheimer’s Disease of Zhejiang Province (ZJAD- 2024001), the Youth Innovation Promotion Association of CAS (2022083), the Initiative Scientific Research Program, the Institute of Zoology, CAS (2023IOZ0202, 2024IOZ0103, 2024IOZ0101, and 2023IOZ0102), the Excellent Young Talents Program of Capital Medical University (12300927and 12500825), the Excellent Young Talents Training Program for the Construction of Beijing Municipal University Teacher Team (BPHR202203105), the Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes (JYY2023-13), the CAS Youth Interdisciplinary Team, the Space Medical Experiment Project of CMSP (HYZHXMH01012), the International Partnership Program of Chinese Academy of Sciences (073GJHZ2023019FN), and the Xuanwu Hospital Elite Cultivation Program (YC20250109).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 1 区 医学
小类 | 1 区 细胞与组织工程 1 区 细胞生物学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 细胞与组织工程 1 区 细胞生物学
第一作者：
第一作者机构： [1]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Aging TranslationalMedicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu HospitalCapital Medical University, Beijing 100053, China
共同第一作者：
通讯作者：
通讯机构： [1]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Aging TranslationalMedicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu HospitalCapital Medical University, Beijing 100053, China [2]State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]University of Chinese Academy of Sciences, Beijing 100049, China [4]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [5]China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China [6]Sino-Danish College, University of Chinese Academy of Sciences, Sino-Danish Center for Education and Research, Beijing 101408, China [7]Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China [13]Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [14]Aging Biomarker Consortium (ABC), Beijing 100101, China
推荐引用方式(GB/T 7714)：
Ying Jing,Huifen Lu,Jingyi Li,et al.Vitamin C conveys geroprotection on primate ovaries[J].Cell Stem Cell.2025,doi:10.1016/j.stem.2025.09.008.
APA：
Ying Jing,Huifen Lu,Jingyi Li,Zan He,Liyun Zhao...&Guang-Hui Liu.(2025).Vitamin C conveys geroprotection on primate ovaries.Cell Stem Cell,,
MLA：
Ying Jing,et al."Vitamin C conveys geroprotection on primate ovaries".Cell Stem Cell .(2025)

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