机构：[1]Department of Clinical Neurosciences and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada[2]Department of Community Health Sciences and O’Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada[3]Department of Paediatrics, Kings Mill Hospital, Sutton in Ashfield, United Kingdom[4]Department of Neurology, University of Pecs, Pecs, Hungary[5]Department of Neurosciences, Neurology, Uppsala University, Uppsala, Sweden[6]Saul R. Korey Department of Neurology, Dominick P. Purpura Department of Neuroscience and Department of Pediatrics, Laboratory of Developmental Epilepsy, Montefiore/Einstein Epilepsy Management Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, U.S.A.[7]Department of Epileptology, Tohoku University School of Medicine, Tohoku, Japan[8]Department of Neurology, Neurological Institute of New York, Columbia University Medical Center, New York, New York, U.S.A.[9]Department of Internal Medicine & Therapeutics, Unit of Clinical and Experimental Pharmacology, University of Pavia and C. Mondino National Neurological Institute, Pavia, Italy[10]Department of Neurology and Psychiatry, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico[11]Department of Neurology, Sree Chitra Tirunal Institute for Medical Science and Technology, Trivandrum, India[12]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China神经内科首都医科大学宣武医院[13]Department of Pediatric Neurology, Red Cross War Memorial Children’s Hospital, University of Cape Town, Cape Town, South Africa
Objective: The International League Against Epilepsy (ILAE) Epilepsy Guidelines Task Force, composed of 14 international members, was established in 2011 to identify, using systematic review methodology, international epilepsy clinical care guidelines, assess their quality, and determine gaps in areas of need of development. Methods: A systematic review of the literature (1985-2014) was performed in six electronic databases (e.g. Medline, Embase) using a broad search strategy without initial limits to language or study design. Six gray literature databases (e.g., American Academy of Neurology [AAN], ILAE) were also searched to minimize publication bias. Two independent reviewers screened abstracts, reviewed full text articles, and performed data abstraction. Descriptive statistics and a meta-analysis were generated. Results: The search identified 10,926 abstracts. Of the 410 articles selected for full text review, 63 met our eligibility criteria for a guideline. Of those included, 54 were in English and 9 were in other languages (French, Spanish, and Italian). Of all guidelines, 29% did not specify the target age groups, 27% were focused on adults, 22% included only children, and 6% specifically addressed issues related to women with epilepsy. Guidelines included in the review were most often aimed at guiding clinical practice for status epilepticus (n = 7), first seizure (n = 6), drug-resistant epilepsy (n = 5), and febrile seizures (n = 4), among others. Most of the guidelines were therapeutic (n = 35) or diagnostic (n = 16) in nature. The quality of the guidelines using a 1-7 point scale (7 = highest) varied and was moderate overall (mean = 4.99 +/- 1.05 [SD]). Significance: We identified substantial gaps in topics (e.g., epilepsy in the elderly) and there was considerable heterogeneity in methodologic quality. The findings should offer a valuable resource for health professionals caring for people with epilepsy, since they will help guide the prioritization, development, and dissemination of future epilepsy-related guidelines.
基金：
International League Against Epilepsy through the Epilepsy Guidelines Task Force; Alberta Innovates [201300150]
第一作者机构：[1]Department of Clinical Neurosciences and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada[2]Department of Community Health Sciences and O’Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
通讯作者：
通讯机构：[*1]Foothills Medical Centre, Department of Clinical Neurosciences, 1403-29th Street NW Room C1209, Calgary, AB T2N 2T9, U.S.A
推荐引用方式(GB/T 7714)：
Khara M. Sauro,Samuel Wiebe,Colin Dunkley,et al.The current state of epilepsy guidelines: A systematic review[J].EPILEPSIA.2016,57(1):13-23.doi:10.1111/epi.13273.
APA：
Khara M. Sauro,Samuel Wiebe,Colin Dunkley,Jozsef Janszky,Eva Kumlien...&Nathalie Jette.(2016).The current state of epilepsy guidelines: A systematic review.EPILEPSIA,57,(1)
MLA：
Khara M. Sauro,et al."The current state of epilepsy guidelines: A systematic review".EPILEPSIA 57..1(2016):13-23
医学