机构：[1]Department of Pathology, The Second Affiliated Hospital of Soochow University, Suzhou, China[2]Department of Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, China[3]Department of Oncology & Radiotherapy, The Second Affiliated Hospital of Soochow University, Suzhou, China.
出处：
ISSN：
摘要：
To investigate the expression of p15(INK4b), p16(INK4a) and p21(Waf1/Cip1) in specimens from cases of normal cervical epithelium (NCE), cervical intraepithelial neoplasia (CIN) and squamous cell carcinoma (SCC), and to evaluate whether there is evidence implicating oncogene-induced senescence (OIS) in cervical squamous cell cancer development.
The immunohistochemical expression of p15(INK4b), p16(INK4a) and p21(Waf1/Cip1) were investigated in formalin-fixed paraffin-embedded specimens from 19 NCE, 51 CIN and 21 SCC cases, respectively. Comparisons among different groups for each marker were performed with Chi-square test.
The expression of p15(INK4b), p16(INK4a) and p21(Waf1/Cip1) were significantly higher in both CIN and SCC compared to NCE. Furthermore, the expression of p15(INK4b) and p21(Waf1/Cip1) was significantly higher in CIN П compared to CIN І, and these expressions were statistically higher in CIN Ш compared to CIN П, respectively. The p16(INK4a) expression was significantly higher in CIN Ш compared to CIN І.
The results suggested that the senescence programs mediated by p15(INK4b), p16(INK4a) and p21(Waf1/Cip1) were activated during the stage of CIN and SCC, and demonstrated that senescence may play important role in preventing from NCE to SCC.
基金：
This study was supported by grants from Jiangsu Natural Science Funding (BK20141185) and Jiangsu Province’s Key Medical Person (RC2011144).
第一作者机构：[1]Department of Pathology, The Second Affiliated Hospital of Soochow University, Suzhou, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Oncology & Radiotherapy, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou 215004, Jiangsu Province, P. R. China.
推荐引用方式(GB/T 7714)：
Zhang Yongsheng,Guo Liangsheng,Xing Pengfei,et al.Increased expression of oncogene-induced senescence markers during cervical squamous cell cancer development.[J].International journal of clinical and experimental pathology.2014,7(12):8911-6.
APA：
Zhang, Yongsheng,Guo, Liangsheng,Xing, Pengfei,Chen, Yuanyuan,Li, Feng...&Lu, Xueguan.(2014).Increased expression of oncogene-induced senescence markers during cervical squamous cell cancer development..International journal of clinical and experimental pathology,7,(12)
MLA：
Zhang, Yongsheng,et al."Increased expression of oncogene-induced senescence markers during cervical squamous cell cancer development.".International journal of clinical and experimental pathology 7..12(2014):8911-6
