机构：[1]Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China[2]Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC[3]School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia[4]Academic Department of Neuroradiology, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London[5]Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, UK[6]Fudan University, Shanghai[7]Beijing Neurosurgical Institute, Beijing研究所北京市神经外科研究所首都医科大学附属天坛医院[8]Jiaozuo People’s Hospital, Henan[9]Ningxia Medical University, Ningxia[10]Jincheng Emergency Medical Rescue Center, Jincheng[11]Affiliated Second Hospital, Hebei Medical University, Hebei, China[12]NIHR University College London Hospitals, Biomedical Research Centre, UCL Institute of Neurology, London[13]Chalfont Centre for Epilepsy, Chalfont St Peter, UK[14]Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, The Netherlands[15]Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China[16]Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Australia
Background and purposeThe International League against Epilepsy (ILAE) updated the classifications of seizures and epilepsies in 2017. The 2017 classifications were compared with the 1980s classifications in rural China. MethodsPeople with epilepsy receiving treatment under the National Epilepsy Control Programme were recruited from rural areas in China. Their seizures and epileptic syndrome were classified using the 1980s ILAE classification system and then re-classified according to the 2017 system. Differences in seizure, epilepsy and aetiology classifications were identified. ResultsA total of 597 individuals (58% males, aged 6-78 years) were included. Amongst them 535 (90%) had a single seizure type, 57 (9.55%) had two types and five (0.84%) had three. There was complete agreement between the 1981 and 2017 classifications for the 525 individuals with focal seizures. Seizures originally classified as generalized in 10 of 65 individuals were re-classified as unknown in the 2017 classification. Compared to the 1980s classifications, the proportion of individuals with unknown seizures and unknown epilepsy increased from 1.2% (7/597) to 2.8% (17/597, P = 0.002), and unknown aetiology increased from 32% (189/597: 182 cryptogenic and seven unclassified) to 39% (230/597; P < 0.001) in the 2017 classifications. ConclusionsThe 1980s and 2017 classifications had 100% agreement in classifying focal seizures and epilepsy in rural China. A small but significant proportion of generalized seizures and epilepsy and aetiologies classified in the old classifications were re-classified to unknown in the new classifications. These results highlight the need for improvement in clinical evaluation of people with epilepsy in resource-poor settings.
基金：
UK Department of Health's NIHR Biomedical Research Centres funding schemeNational Institute for Health Research (NIHR); Dr Marvin Weil Epilepsy Research Fund; NINDS/Fogarty grant [R21NS069223-01]; Key Research Project of the Chinese Ministry of Science and Technology [2016YFC0904400]
通讯机构：[*1]Department of Neuroscience, Central Clinical School, Monash University Level 6, The Alfred Centre, 99 Commercial Road, Melbourne, VIC 3004, Australia
推荐引用方式(GB/T 7714)：
F. Wang,Z. Chen,I. Davagnanam,et al.Comparing two classification schemes for seizures and epilepsy in rural China[J].EUROPEAN JOURNAL OF NEUROLOGY.2019,26(3):422-427.doi:10.1111/ene.13857.
APA：
F. Wang,Z. Chen,I. Davagnanam,C. Hoskote,D. Ding...&P. Kwan.(2019).Comparing two classification schemes for seizures and epilepsy in rural China.EUROPEAN JOURNAL OF NEUROLOGY,26,(3)
MLA：
F. Wang,et al."Comparing two classification schemes for seizures and epilepsy in rural China".EUROPEAN JOURNAL OF NEUROLOGY 26..3(2019):422-427
