Background: Very satisfactory clinical effects have been achieved in treatment of osteoarthritis of knee with intraarticular injection of sodium hyaluronate (SH) allied with steroid hormones for nerve block. How will such allied treatment be used for periarthritis of shoulder? Objective: To probe into the improvement of pain and joint function in periarthritis of shoulder treated with integration of intraarticular injection of SH with nerve and pain block with betamethasone. Design: Self-control was designed before and after experiment. Setting: Beijing Tiantan Hospital, Capital University of Medical Sciences. Participants: Twenty patients with periarthritis of shoulder were included, aged from 40 to 65 years from Pain Clinic of Beijing Tiantan Hospital affiliated to Capital University of Medical Sciences from January to October 2004. Methods: Integration of intraarticular injection of SH with nerve and pain block with betamethasone was applied to treat 20 cases of periarthritis of shoulder and the record was done before treatment and 1 week after treatment. 1 Pain: visual analogue scale (VAS) was adopted, in which, "no any pain sensation" was 0 score, "unable to bear pain with imagination" was 10 scores. Pain score was recorded during quiet and movement stages. 2 Evaluation of daily life activity: 5 grades were involved. 4 scores indicated being impossible completely, 3 scores indicate being possible with help, 2 scores indicate being possibled reluctantly and mostly feeling inconvenient, 1 score indicated being possible reluctantly without inconvenience and 0 score indicated being possible as healthy person. Main outcome measures: 1 Evaluation of pain during quiet and moving stages in patients with periarthritis of shoulder. 2 Evaluation of daily life activity. Results: According to practical management and analysis, 20 cases en- tered result analysis. 1 VAS at quiet stage: it was lower 1 week after treatment compared with that before treatment [(4.34±1.33),(8.27±1.37)scores, P < 0.01]. 2 VAS at moving stage: it was lower 1 week after treatment compared with that before treatment [(4.73±1.31),(8.49±1.35) scores, P < 0.011. 3 VAS of daily life activity: it was lower 1 week after treatment compared with that before treatment [(1.10±0.74),(3.30±0.48) scores, P < 0.01]. Conclusion: Integration of intraarticular injection of SH with nerve and pain block with betamethasone treats effectively periarthritis of shoulder, without remarkably harmful reaction and it is worth in popularization in treatment of pain.