Background: Conservative treatment of osseous gonarthritis (OG) is mainly to reduce the loading of knee joint and maintain muscle exercise, and non-steroidal anti-inflammatory drugs serve as supplements in case of acute occurrence. Objective: To investigate the effect of combination of intraarticular injection of hyaluronate and pain-point injection of betamethasone in improving the pain symptom in patients with OG. Design: Open experiment. Setting: Beijing Tiantan Hospital affiliated to Capital University of Medical Sciences. Participants: We selected 45 OG patients, who were aged 40 to 85 years and received treatment in the clinic of Beijing Tiantan Hospital affiliated to Capital University of Medical Sciences between January 2004 and October 2004. Methods: OG parenteral solution was intraarticularly injected into the knee joint, 2.5 mL once a week, 5 weeks set as a disease course. Pain points around knee joint were searched for following thorough physical examination. Anti-inflammatory analgesic solution of 2.0-3.0 mL was injected at each pain point. Physical examination was repeated before treatment in each week. Injection at pain points was maintained if they were still present. Intraarticular injection of hyaluronate was performed only when the pain points disappeared after treatment. Main outcome measures: 1 Pain score at rest and at exercise. 2 Time when pain disappeared and times of betamethasone administration. Results: Totally 45 patients entered the result analysis. 1 Pain at rest and at exercise 1 week after combination treatment of intraarticular injection of hyaluronate and pain-point injection of betamethasone was significantly lessened compared to that before treatment (P < 0.01). Pain relief was more significant at rest than at exercise (P < 0.01). 2 Pain disappeared at (17.07±6.00)days after treatment on average. The average times of betamethasone administration was (2.42±0.78) times. 3 No local joint pain and other adverse reactions occurred after administration in any case. Conclusion: Combination of intraarticular injection of hyaluronate and pain-point injection of betamethasone can effectively relieve the pain symptom of osseous gonarthritis, with no obvious adverse reactions.