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microRNAs: important regulators of stem cells

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收录情况： ◇ SCIE

作者：

机构： [1]Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China; [2]Capital Med Univ, Beijing Anzhen Hosp, 2 Anzhen Rd, Beijing, Peoples R China; [3]Guilin Med Univ, Guilin 541004, Guangxi, Peoples R China

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关键词： Stem cell miRNAs Reprogramming Pluripotency Differentiation

摘要：

Stem cells are undifferentiated cells and have multilineage differentiation potential. Generally, stem cells are classified into adult stem cells, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Stem cells have great potential in clinical therapy due to their pluripotency and self-renewal ability. microRNAs (miRNAs) are small non-coding RNAs which are evolutionarily conserved and participate in the pathogenesis of many diseases, cell cycle regulation, apoptosis, aging, cell fate decisions, and different signaling pathways. Different kinds of stem cells possess distinct miRNA expression profiles. Our review summarizes the critical roles of miRNAs in stem cell reprogramming, pluripotency maintenance, and differentiation. In the future, miRNAs may greatly contribute to stem cell clinical therapy and have potential applications in regenerative medicine.

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中科院(CAS)分区：

出版当年[2016]版：

大类 | 2 区医学

小类 | 2 区医学：研究与实验 3 区细胞生物学

最新[2025]版：

大类 | 2 区

医学

小类 | 2 区细胞与组织工程 2 区细胞生物学 2 区医学：研究与实验

JCR分区：

出版当年[2015]版：

Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q2 CELL BIOLOGY

最新[2024]版：

Q1 CELL & TISSUE ENGINEERING Q1 CELL BIOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 7.3 最新[2024版] 7.9 最新五年平均 4.504 出版当年[2015版] 4.814 出版当年五年平均 3.368 出版前一年[2014版] 4.211 出版后一年[2016版]

第一作者：

第一作者机构： [1]Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China;

通讯作者：

通讯机构： [1]Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China;

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