机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China神经科系统神经内科[2]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China[3]Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China科技平台中美神经科学研究所[4]National Clinical Research Center for Geriatric Diseases, Beijing, China国家老年疾病临床医学研究中心[5]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, Michigan, USA[6]Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA[7]Department of Neurosurgery, Gates Vascular Institute at Kaleida Health, Buffalo, NY, USA[8]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China医技科室放射科[9]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China神经科系统神经外科[10]Department of Radiology, Chaoyang Hospital, China
Objective Cerebral blood flow (CBF) mapping of single-photon emission tomography (SPECT) is considered a gold standard for evaluating cerebral perfusion. However, invasiveness, high costs and strict technical requirements can limit its clinical use. We aimed to evaluate the concordance of CBF maps obtained from SPECT and pseudo-continuous arterial spin labeling magnetic resonance (PCASL-MR) imaging for evaluating cerebral perfusion. Methods PCASL-MR/SPECT-CBF maps were obtained from 16 eligible patients with unilateral middle cerebral artery stenosis (MCAS). Three slices (basal ganglia, semi-oval center and cerebellum) on both PCASL-MR and SPECT maps were divided into different regions of interest (ROIs) according to the ASPECT criterion, arterial territories, and cerebral hemispheres, respectively. The concordance of the two types of CBF maps and the specificity and sensitivity of PCASL-MR imaging on predicting regional hypoperfusion were calculated. Results A total of 448 ROIs were divided according to the ASPECT criterion, 192 ROIs partitioned in accordance with arterial territories, and 96 ROIs delineated based on cerebral hemispheres were analyzed. PCASL-MR imaging exhibited 83.78% to 100% sensitivity, 90.19% to 95.83% specificity for detection of hypoperfusion. Qualitative analyses revealed a strong concordance between PCASL-MR and SPECT on reflecting regional cerebral hypoperfusion (Kappa coefficient = 0.662-0.920, p < 0.01). Semi-quantitative analysis by Delta CBF revealed moderate consistency (Spearman correlation coefficient = 0.610-0.571). Conclusions Our findings suggest that PCASL-MR may be a promising non-invasive, inexpensive alternative to SPECT for evaluating cerebral perfusion accurately in patients with symptomatic MCAS.
第一作者机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China[2]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China[3]Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China[4]National Clinical Research Center for Geriatric Diseases, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China[2]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China[3]Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China[4]National Clinical Research Center for Geriatric Diseases, Beijing, China[8]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China[10]Department of Radiology, Chaoyang Hospital, China
推荐引用方式(GB/T 7714)：
Ya Jingyuan,Zhou Da,Ding Jiayue,et al.Arterial spin labeling-MR may be an alternative to SPECT for evaluating cerebral perfusion in patients with unilateral middle cerebral artery stenosis[J].NEUROLOGICAL RESEARCH.2020,42(8):621-629.doi:10.1080/01616412.2020.1782080.
APA：
Ya, Jingyuan,Zhou, Da,Ding, Jiayue,Rajah, Gary B.,Wu, Ye...&Meng, Ran.(2020).Arterial spin labeling-MR may be an alternative to SPECT for evaluating cerebral perfusion in patients with unilateral middle cerebral artery stenosis.NEUROLOGICAL RESEARCH,42,(8)
MLA：
Ya, Jingyuan,et al."Arterial spin labeling-MR may be an alternative to SPECT for evaluating cerebral perfusion in patients with unilateral middle cerebral artery stenosis".NEUROLOGICAL RESEARCH 42..8(2020):621-629
