机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China神经科系统神经内科首都医科大学宣武医院[2]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, United States[3]Department of Rehabilitation, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China[4]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
ObjectivesTo explore the alterations in immune cell composition in peripheral blood in patients with acute ischemic stroke (AIS) based on their age group. MethodsPatients with imaging confirmed AIS were enrolled from April 2019 to January 2020 and were divided into three groups according to their ages: <55 years (group-A), 55-65 years (group-B), and >65 years (group-C). Blood samples were collected immediately when the patients were admitted to our ward prior to any intervention. Flow cytometry was used to analyze immune cell composition in peripheral blood. ResultsA total of 41 eligible patients were included for final analysis. Among the three groups, the proportions of CD56(+) CD16dim NK cells were least to greatest in group-B, group-A, then group-C, respectively. With increasing age, there was a decrease in the proportion of CD3(+) T-cells (group-A vs. group-C, P = 0.016) and CD3+CD4+ T-cells (group-C vs. group-A, P = 0.008; group-C vs. group-B P = 0.026). Meanwhile, no significant differences in proportions of monocytes and B cells were observed. ConclusionsThe compositions of immune cells in peripheral blood of AIS patients were distinct when divided by age groups. Differences in immune cell ratios may affect clinical outcomes and foreshadows possible need for customized treatment of AIS in different age groups.
基金：
This work was supported by the National Key R&D Program
of China under Grant 2017YFC1308400; the National
Natural Science Foundation under Grants 81801143,
82171297, and 82101390; the Beijing Natural Science
Foundation 7212047.
第一作者机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China[4]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
推荐引用方式(GB/T 7714)：
Zhang Haiyue,Guan Jingwei,Lee Hangil,et al.Immunocytes Rapid Responses Post-ischemic Stroke in Peripheral Blood in Patients With Different Ages[J].FRONTIERS IN NEUROLOGY.2022,13:doi:10.3389/fneur.2022.887526.
APA：
Zhang, Haiyue,Guan, Jingwei,Lee, Hangil,Wu, Chuanjie,Dong, Kai...&Meng, Ran.(2022).Immunocytes Rapid Responses Post-ischemic Stroke in Peripheral Blood in Patients With Different Ages.FRONTIERS IN NEUROLOGY,13,
MLA：
Zhang, Haiyue,et al."Immunocytes Rapid Responses Post-ischemic Stroke in Peripheral Blood in Patients With Different Ages".FRONTIERS IN NEUROLOGY 13.(2022)
