研究单位：[1]China National Center for Cardiovascular Diseases[2]Beijing Anzhen Hospital[3]The Affiliated Hospital of Xuzhou Medical University[4]Tibet Autonomous Region People's Hospital[5]Beijing Tiantan Hospital[6]Xuanwu Hospital, Beijing[7]Chaowu Yan,Beijing 1816670,Beijing Municipality 2038349,China,100037[8]National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences,Fuwai Hospital,Beijing 1816670,Beijing Municipality 2038349,China,100037
This study aims to (1) investigate the internal microstructure of patent foramen ovale related to cryptogenic stroke, transient ischemic attack or migraine and determine the effectiveness of transcatheter closure in these patients; (2) evaluate the microstructural features of asymptomatic patients with PFO and make a follow-up；(3) perform an untargeted metabolomics analysis using plasma samples from right atrium and left atrium and shunt provocative test was conducted;(4) collect the blood sample from PFO tunnel;(5) cardiac CTA was performed to evaluate the position and morphology of device.
