研究单位:[1]Xuanwu Hospital Capital Medical University,Beijing,Beijing,China,100053[2]Changping Laboratory
研究目的:
The goal of this clinical trial is to learn if electrical stimulation targeting the Somato-Cognitive Action Network (SCAN) can improve motor symptoms in adults with idiopathic Parkinson's disease (PD). It will also evaluate the safety of this treatment. The main questions it aims to answer are: - Does electrical stimulation targeting SCAN reduce motor symptoms (measured by MDS-UPDRS-III scores) in PD patients after 3 months? - Is SCAN electrical simulation (SES) a safe and tolerable treatment for PD, with minimal adverse effects? Researchers will compare participants' baseline motor function to their post-treatment results to determine if SES is effective. Participants will: - First undergo non-invasive brain stimulation (iTBS) to test responsiveness. - If eligible, receive surgical implantation of SES electrodes in the personalized SCAN target. - Complete follow-up visits for 12 months to monitor symptoms, side effects, and quality of life.