Dementia causes a substantial global economic burden, but effective treatment is lacking. Recently, studies have revealed that gamma-band waves of electrical brain activity, particularly 40 Hz oscillations, are closely associated with high-order cognitive functions and can activate microglia to clear amyloid-beta deposition. Here, we found that compared with sham stimulation, applying 40-Hz high-frequency repetitive transcranial magnetic stimulation (rTMS) over the bilateral angular gyrus in patients with probable Alzheimer's disease (AD; n = 37) resulted in up to 8 weeks of significantly improved cognitive function. Power spectral density analysis of the resting-state electroencephalography (EEG) demonstrated that 40-Hz rTMS modulated gamma-band oscillations in the left posterior temporoparietal region. Further testing with magnetic resonance imaging and TMS-EEG revealed the following: 40-Hz rTMS 1) prevented gray matter volume loss, 2) enhanced local functional integration within bilateral angular gyrus, as well as global functional integration in bilateral angular gyrus and the left middle frontal gyrus, 3) strengthened information flow from the left posterior temporoparietal region to the frontal areas and strengthened the dynamic connectivity between anterior and posterior brain regions. These findings demonstrate that modulating gamma-band oscillations effectively improves cognitive function in patients with probable AD by promoting local, long-range, and dynamic connectivity within the brain.
基金：
National Key R&D Program (No. 2018YFC1314500, 2018YFC-
1314504); National Natural Science Foundation of China (No.
62176044, 81701297, 81801124, 82071483); Sichuan Science and
Technology Program (2021YJ0186).
第一作者机构：[1]Capital Med Univ, Xuanwu Hosp, Dept Neurol, 45 Changchun St, Beijing 100053, Peoples R China[2]Beijing Key Lab Neuromodulat, Beijing, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Capital Med Univ, Xuanwu Hosp, Dept Neurol, 45 Changchun St, Beijing 100053, Peoples R China[2]Beijing Key Lab Neuromodulat, Beijing, Peoples R China[4]Capital Med Univ, Beijing Inst Brain Disorders, Inst Sleep & Consciousness Disorders, Beijing, Peoples R China[6]Kunming Univ Sci & Technol, Inst Primate Translat Med, State Key Lab Primate Biomed Res, Middle boda Rd, Kunming 650504, Yunnan, Peoples R China[7]Peking Univ, Peking Univ Third Hosp, Beijing Key Lab MRI Devices & Technol, Dept Neurol, 49 North Garden Rd, Beijing 100191, Peoples R China[*1]State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Middle boda Road, 650504 Kunming, China.[*2]Beijing Key Laboratory of MRI Devices and Technology, Department of Neurology, Peking University Third Hospital, School of Medical Technology of Peking University, 49 North Garden Rd., Beijing 100191, China.[*3]Department of Neurology, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, 100053 Beijing, China
推荐引用方式(GB/T 7714)：
Liu Chunyan,Han Tao,Xu Zhexue,et al.Modulating Gamma Oscillations Promotes Brain Connectivity to Improve Cognitive Impairment[J].CEREBRAL CORTEX.2022,32(12):2644-2656.doi:10.1093/cercor/bhab371.
医学