机构：[1]School of Ethnology and Sociology, Yunnan University, Kunming, China[2]The Mental Health Center, Yunnan University, Kunming, China[3]Neurology Department, Xuan Wu Hospital of Capital Medical University, Beijing, China神经科系统神经内科首都医科大学宣武医院[4]Qingdao Mental Health Center, Qingdao University, Qingdao, China[5]Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China[6]CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing 100101, China[7]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
Objective Existing studies have shown that thyroid dysfunction is associated with depression. However, its role in major depressive disorder (MDD) with comorbid anxiety remains unclear. The main purpose of this study was to compare thyroid function in a large sample of first episode drug naive (FEDN) MDD patients with and without anxiety. Methods This cross-sectional study examined 1718 outpatients who were drug-naive and diagnosed as MDD at first episode. Socio-demographic and clinical data, as well as thyroid function-related parameters, including free thyroxine (FT4), free triiodothyronine (FT3), thyroid-stimulating hormone (TSH), thyroid peroxidase antibodies (TPOAb) and anti-thyroglobulin (TGAb), were evaluated. The Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA) and the positive subscale of the Positive and Negative Syndrome Scale (PANSS) were used to evaluate depressive, anxiety and psychotic symptoms, respectively. Results Compared to MDD patients without anxiety, MDD patients with anxiety were more likely to have more suicide attempts and psychotic symptoms, as well as higher serum levels of TSH, TPOAb and TGAb (all p < 0.001). Among patients with abnormally elevated serum TSH, TPOAb, and TGAb, 83.5% (872/1044), 89.3% (391/438) and 89.6% (266/297) had comorbid anxiety disorders, respectively. The odds ratio between patients with comorbid and without comorbid anxiety was 1.657 (95% CI 1.304-2.105) for elevated TSH levels, 1.943 (95% CI 1.444-2.613) for elevated TGAb levels, and 2.448 (95% CI 1.760-3.403) for elevated TPOAb levels. Furthermore, multivariable linear analysis showed that elevated TSH and TGAb were significant predictors of anxiety in MDD patients. Conclusions Our results suggest that comorbid anxiety in FEDN MDD patients is positively associated with elevated TSH and TGAb levels, which may be promising biomarkers of comorbid anxiety in MDD patients. Clinical treatment of impaired thyroid function may be useful for comorbid anxiety in MDD patients.
基金：
Double First Class University Plan, National Key R amp; D Program of China [2017YFE0103700]; Kunming Psychiatric Hospital
第一作者机构：[1]School of Ethnology and Sociology, Yunnan University, Kunming, China[2]The Mental Health Center, Yunnan University, Kunming, China
通讯作者：
通讯机构：[6]CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing 100101, China[7]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
推荐引用方式(GB/T 7714)：
Yang Wanqiu,Qu Miao,Jiang Rui,et al.Association between thyroid function and comorbid anxiety in first-episode and drug naive patients with major depressive disorder[J].EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE.2023,273(1):191-198.doi:10.1007/s00406-022-01457-x.
APA：
Yang, Wanqiu,Qu, Miao,Jiang, Rui,Lang, XiaoE&Zhang, Xiang-Yang.(2023).Association between thyroid function and comorbid anxiety in first-episode and drug naive patients with major depressive disorder.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,273,(1)
MLA：
Yang, Wanqiu,et al."Association between thyroid function and comorbid anxiety in first-episode and drug naive patients with major depressive disorder".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE 273..1(2023):191-198
