机构：[1]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.[2]Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.[3]Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.[4]Xuan Wu Hospital, Capital Medical University, Beijing, China.首都医科大学宣武医院[5]Academy of Psychology and Behavior, Tianjin Normal University, Tianjin, China.[6]School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China.[7]Speech and Hearing Research Center, Key Laboratory on Machine Perception (Ministry of Education), Peking University, Beijing, China.
Alzheimer's disease (AD) has been confirmed as an influencing factor of visual impairment, but potential concomitant effects on visual and cognitive performance are not well understood.To provide a new method for early screening of Alzheimer's disease and further explore the theoretical mechanism of the decline of whole visual and cognitive performance in AD.We studied 60 individuals without dementia as normal control (NC), 74 individuals with subjective cognitive decline (SCD), 60 individuals with amnesia mild cognitive impairment (aMCI), and 75 patients with AD on a battery of tests designed to measure multiple aspects of basic and higher-order visual perception and cognition. All subjects performed on same visual and cognitive test batteries.The results showed both of four groups, with the stimulus-presentation time being longer, the visual-search performance improved, and both the eye interest-area first fixation duration and the interest-area-fixation count increased. Particularly under the noise-masking condition, the AD group performed the worst at stimulus-presentation times between 300 and 900 ms. The aMCI group, but not the SCD group, performed worse than the NC group at the stimulus-presentation time of either 300 or 500 ms. The interest-area-fixation count was higher in all the patient groups than that in the NC group, and distinguishable between participants with AD and those with SCD or aMCI.The visual-search performance combined with eye-movement tracking under the noise-masking condition can be used for distinguishing AD from normal aging, SCD, and aMCI.
基金：
“973’National Basic Research Program of China
(2015CB351800) (for the design of the study, the
collection, analysis, and interpretation of data, and
writing the manuscript), the National Natural Science
Foundation of China (31771252, 81970996 )(for the
design of the study, the collection, analysis, and inter-
pretation of data, and writing the manuscript), and
the Tianjin Philosophy and Social Science Project
(TJJX 15-002)(for the design of the study, the collec-
tion, analysis, and interpretation of data, and writing
the manuscript).
第一作者机构：[1]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.[2]Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.[3]Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
通讯作者：
通讯机构：[1]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.[2]Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.[6]School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China.[7]Speech and Hearing Research Center, Key Laboratory on Machine Perception (Ministry of Education), Peking University, Beijing, China.[*1]School of Psychological and Cognitive Sciences, BeijingKey Laboratory of Behavior and Mental Health, Peking University, Beijing, China
推荐引用方式(GB/T 7714)：
Xue Chuanwei,Tang Yi,Wang Changming,et al.The Effects of Normal Aging, Subjective Cognitive Decline, Mild Cognitive Impairment, or Alzheimer's Disease on Visual Search[J].JOURNAL OF ALZHEIMERS DISEASE.2022,88(4):1639-1650.doi:10.3233/JAD-220209.
APA：
Xue Chuanwei,Tang Yi,Wang Changming,Yang Haibo&Li Liang.(2022).The Effects of Normal Aging, Subjective Cognitive Decline, Mild Cognitive Impairment, or Alzheimer's Disease on Visual Search.JOURNAL OF ALZHEIMERS DISEASE,88,(4)
MLA：
Xue Chuanwei,et al."The Effects of Normal Aging, Subjective Cognitive Decline, Mild Cognitive Impairment, or Alzheimer's Disease on Visual Search".JOURNAL OF ALZHEIMERS DISEASE 88..4(2022):1639-1650
