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Functional molecular expression of nature killer cells correlated to HBsAg clearance in HBeAg-positive chronic hepatitis B patients during PEG-IFN α-2a therapy

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Cao Weihua[1,2] * ; Lu Huihui[1,3] * ; Zhang Luxue[1,4] * ; Wang Shiyu[1] * ; Deng Wen[1] * ; Jiang Tingting[1] * ; Lin Yanjie[5] ; Yang Liu[1] ; Bi Xiaoyue[1] ; Lu Yao[1] ; Zhang Lu[1] ; Shen Ge[1] ; Liu Ruyu[1] ; Chang Min[1] ; Wu Shuling[1] ; Gao Yuanjiao[1] ; Hao Hongxiao[1] ; Xu Mengjiao[1] ; Chen Xiaoxue[1] ; Hu Leiping[1] ; Xie Yao[1,5] ; Li Minghui[1,5] ;
机构： [1]Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China, [2]Department of Infectious Diseases, Miyun Teaching Hospital, Capital Medical University, Beijing, China, [3]Department of Obstetrics and Gynecology, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, [4]Infectious Disease Department, Xuanwu Hospital, Capital Medical University, Beijing, China, [5]Department of Hepatology Division 2, Peking University Ditan Teaching Hospital, Beijing, China
出处：
DOI： 10.3389/fimmu.2022.1067362
ISSN：

关键词： nature killer cells chronic hepatitis B PEG-IFN a-2a hepatitis B virus HBsAg loss

摘要：
To explore whether the frequencies and functional molecules expression of Natural Killer cells (NK cells) are related to hepatitis B surface antigen (HBsAg) disappearance in hepatitis B e envelope antigen (HBeAg)-positive patients with chronic hepatitis B (CHB) throughout peginterferon alpha-2a (PEG-IFN α-2a) treatment.In this prospective research, HBeAg-positive patients with CHB received PEG-IFN α-2a treatment, completing 4-year follow-up. After PEG-IFN α-2a treatment, undetectable HBV DNA, HBsAg loss, and HBeAg disappearance were defined as functional cure. Proportions of NK, CD56dim, CD56bright, NKp46+, NKp46dim, NKp46high, and interferon alpha receptor 2 (IFNAR2)+ NK cells, and the mean fluorescence intensity (MFI) of NK cell surface receptors IFNAR2 and NKp46 were detected.66 patients were enrolled into the study in which 17 patients obtained functional cure. At baseline, hepatitis B virus desoxyribose nucleic acid (HBV DNA) titer in patients with functional cure was remarkably lower than that in Non-functional cure group. Compared with baseline, HBV DNA levels, HBsAg levels, and HBeAg levels significantly declined at week 12 and 24 of therapy in patients with functional cure. At baseline, the negative correlation between CD56bright NK% and HBV DNA and the negative correlation between CD56dim NK% and HBV DNA was showed; CD56bright NK% and IFNAR2 MFI in patients with functional cure were remarkably higher than those in patients without functional cure. After therapy, CD56bright NK% and NKp46high NK% in patients with functional cure were higher than those in patients without functional cure. In Functional cure group, after 24 weeks of treatment NK%, CD56bright NK%, IFNAR2 MFI weakly increased, and NKp46high NK% and NKp46 MFI significantly increased, meanwhile, CD56dim NK% and NKp46dim NK% decreased. Only NKp46 MFI increased after therapy in patients without functional cure.The lower HBV DNA load and the higher CD56bright NK% before therapy, and the higher the post-treatment CD56bright NK%, IFNAR2 MFI, NKp46high NK%, the easier to achieve functional cure.Copyright © 2022 Cao, Lu, Zhang, Wang, Deng, Jiang, Lin, Yang, Bi, Lu, Zhang, Shen, Liu, Chang, Wu, Gao, Hao, Xu, Chen, Hu, Xie and Li.

基金：
The study was supported by Beijing Hospitals Authority Clinical medicine Development of special funding support (XMLX 202127); The capital health research and development of special (2022–1–2172); National Science and Technology Major Project of China (2017ZX10201201-001-006, 2017ZX10201201-002-006, 2018ZX10715-005-003-005); Highlevel Public Health Technical Personnel Training Program of Beijing Municipal Health Commission (2022–3–050); The Digestive Medical Coordinated Development Center of Beijing Hospitals Authority (XXZ0302 and XXT28); Project supported by Beijing science and technology commission (Z211100002921059).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 2 区 医学
小类 | 2 区 免疫学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 免疫学
JCR分区：
出版当年[2020]版：
Q1 IMMUNOLOGY
最新[2023]版：
Q1 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China, [2]Department of Infectious Diseases, Miyun Teaching Hospital, Capital Medical University, Beijing, China,
共同第一作者：
通讯作者：
通讯机构： [1]Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China, [5]Department of Hepatology Division 2, Peking University Ditan Teaching Hospital, Beijing, China
推荐引用方式(GB/T 7714)：
Cao Weihua,Lu Huihui,Zhang Luxue,et al.Functional molecular expression of nature killer cells correlated to HBsAg clearance in HBeAg-positive chronic hepatitis B patients during PEG-IFN α-2a therapy[J].FRONTIERS IN IMMUNOLOGY.2022,13:1067362.doi:10.3389/fimmu.2022.1067362.
APA：
Cao Weihua,Lu Huihui,Zhang Luxue,Wang Shiyu,Deng Wen...&Li Minghui.(2022).Functional molecular expression of nature killer cells correlated to HBsAg clearance in HBeAg-positive chronic hepatitis B patients during PEG-IFN α-2a therapy.FRONTIERS IN IMMUNOLOGY,13,
MLA：
Cao Weihua,et al."Functional molecular expression of nature killer cells correlated to HBsAg clearance in HBeAg-positive chronic hepatitis B patients during PEG-IFN α-2a therapy".FRONTIERS IN IMMUNOLOGY 13.(2022):1067362

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