机构：[1]Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.外科系统眼科首都医科大学宣武医院[3]Department of Ophthalmology, the Second Hospital of Anhui Medical University, Hefei 230011, Anhui Province, China.[4]Department of Ophthalmology, Beijing Liangxiang Hospital, Capital Medical University, Beijing 102401, China.[5]Department of Ophthalmology, Fuxing Hospital, Capital Medical University, Beijing 100045, China.[6]Cardiology Department, Kailuan General Hospital, Tangshan 063001, Hebei Province, China.[7]Health Care Center, Kailuan Group, Tangshan 063000, Hebei Province, China.[8]Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Heidelberg 68167, Germany.
To investigate the risk and protective factors associated with the retinal nerve fiber layer defect (RNFLD) in a Chinese adult population.This study was a cross-sectional population-based investigation including employees and retirees of a coal mining company in Kailuan City, Hebei Province. All the study participants underwent a comprehensive systemic and ophthalmic examination. RNFLD was diagnosed on fundus photographs. Binary logistic regression was used to investigate the risk and protective factors associated with the RNFLD.The community-based study included 14 440 participants. There were 10 473 participants in our study, including 7120 males (68.0%) and 3353 females (32.0%). The age range was 45-108y, averaging 59.56±8.66y. Totally 568 participants had RNFLD and the prevalence rate was 5.42%. A higher prevalence of RNFLD was associated with older age [P<0.001, odds ratio (OR): 1.032; 95% confidence interval (CI): 1.018-1.046], longer axial length (P=0.010, OR: 1.190; 95%CI: 1.042-1.359), hypertension (P=0.007, OR: 0.639; 95%CI: 0.460-0.887), and diabetes mellitus (P=0.019, OR: 0.684; 95%CI: 0.499-0.939). The protective factors of RNFLD were visual acuity (P=0.038, OR: 0.617; 95%CI: 0.391-0.975), and central anterior chamber depth (P=0.046, OR: 0.595; 95%CI: 0.358-0.990).In our cross-sectional community-based study, with an age range of 45-108y, RNFLD is associated with older age, longer axial length, hypertension, and diabetes mellitus. The protective factors of RNFLD are visual acuity and central anterior chamber depth. These can help to predict and evaluate RNFLD related diseases and identify high-risk populations early.International Journal of Ophthalmology Press.
第一作者机构：[1]Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.[2]Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
通讯作者：
通讯机构：[1]Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.[*1]Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology ＆ Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Dongjiaominxiang Street, No.1, Dongcheng District, Beijing 100730, China
推荐引用方式(GB/T 7714)：
Wang Ye-Nan,Wang Ya-Xing,Zhou Jin-Qiong,et al.Analysis of risk and protective factors associated with retinal nerve fiber layer defect in a Chinese adult population[J].INTERNATIONAL JOURNAL OF OPHTHALMOLOGY.2023,16(3):427-433.doi:10.18240/ijo.2023.03.14.
APA：
Wang Ye-Nan,Wang Ya-Xing,Zhou Jin-Qiong,Wan Qian-Qian,Fang Li-Jian...&Jonas Jost B.(2023).Analysis of risk and protective factors associated with retinal nerve fiber layer defect in a Chinese adult population.INTERNATIONAL JOURNAL OF OPHTHALMOLOGY,16,(3)
MLA：
Wang Ye-Nan,et al."Analysis of risk and protective factors associated with retinal nerve fiber layer defect in a Chinese adult population".INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 16..3(2023):427-433
