机构：[a]Department of Ophthalmology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China眼科首都医科大学宣武医院[b]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China神经内科首都医科大学宣武医院[c]Center laboratory, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China首都医科大学宣武医院[d]Anaesthetics, Pain Medicine & Intensive Care, Department of Surgery & Cancer, Imperial College London, Chelsea and Westminster Hospital, SW10 9NH London, United Kingdom
Alzheimer's disease (AD) patients often have visual disorders which may be due to retinal nerve degenerative changes. The aim of the current study was to determine the thickness changes of retina nerve fibers with optical coherence tomography (OCT) in AD patients. The OCT was used to assess the thickness of retinal nerve fiber layer (RNFL) from 22 AD patients and 22 healthy age-matched controls. The corrected visual acuity and intraocular pressure were measured and the dilated fundus examination and fundus image acquisition were also performed in those subjects. Compared with healthy age-matched controls, the RNFL thickness of AD patients were much thinner (p < 0.05), especially in supra-retina and infra-retina, while no difference was found in the other retinal area. These changes were also confirmed by the fundus images. In conclusion, retinal nerve degeneration is present in the retina of AD patients and this degeneration is likely localized preferentially to the superior and inferior quadrant. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
基金：
the National Natural Science Foundation of China (30772288) and Beijing Municipal Natural Science Foundation (7082043).
第一作者机构：[a]Department of Ophthalmology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China
通讯作者：
通讯机构：[a]Department of Ophthalmology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Yan Lu,Zhen Li,Xinqing Zhang,et al.Retinal nerve fiber layer structure abnormalities in early Alzheimer's disease: Evidence in optical coherence tomography[J].NEUROSCIENCE LETTERS.2010,480(1):69-72.doi:10.1016/j.neulet.2010.06.006.
APA：
Yan Lu,Zhen Li,Xinqing Zhang,Baoquan Ming,Jianping Jia...&Daqing Ma.(2010).Retinal nerve fiber layer structure abnormalities in early Alzheimer's disease: Evidence in optical coherence tomography.NEUROSCIENCE LETTERS,480,(1)
MLA：
Yan Lu,et al."Retinal nerve fiber layer structure abnormalities in early Alzheimer's disease: Evidence in optical coherence tomography".NEUROSCIENCE LETTERS 480..1(2010):69-72
