机构：[1]Department of Ophthalmology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China.眼科首都医科大学宣武医院[2]Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 453003, China.[3]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China.神经内科首都医科大学宣武医院[4]Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, UK.
Background: Alzheimer's disease (AD) is the most common form of dementia and patients often have visual disorders. Mild cognitive impairment (MCI) is characterized by a memory deficit when compared with those of a similar age and education level which could indicate an earlier onset of AD. The aim of this study is to measure the changes of the retinal nerve fiber layer (RNFL) thickness of AD and MCI patients in comparison with the normal age controls. Methods: The RNFL thickness was assessed using optical coherence tomography (OCT) in patients with MCI, AD (mild, moderate and severe) and the age matched controls. Results: The thickness of RNFL in the superior quadrant and total mean values are gradually and significantly decreased from MCI to severe AD when compared to that in the controls. There is also a significant reduction of the retinal nerve fiber layer in the inferior quadrant in severe AD patients. Conclusions: Our data indicate that the retinal nerve fiber layer degeneration is paralleled with dementia progression. Owing to its non-invasive and cost effective nature, monitoring RNFL thickness may have a value in assessing disease progression and the efficacy of any treatments.
基金：
Beijing Municipal Science & Technology Commission (Z141107002514116).
第一作者机构：[1]Department of Ophthalmology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Ophthalmology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Dachuan Liu,Lina Zhang,Zhen Li,et al.Thinner changes of the retinal nerve fiber layer in patients with mild cognitive impairment and Alzheimer's disease[J].BMC NEUROLOGY.2015,15(1):14.doi:10.1186/s12883-015-0268-6.
APA：
Dachuan Liu,Lina Zhang,Zhen Li,Xuxiang Zhang,Yue Wu...&Yan Lu.(2015).Thinner changes of the retinal nerve fiber layer in patients with mild cognitive impairment and Alzheimer's disease.BMC NEUROLOGY,15,(1)
MLA：
Dachuan Liu,et al."Thinner changes of the retinal nerve fiber layer in patients with mild cognitive impairment and Alzheimer's disease".BMC NEUROLOGY 15..1(2015):14
