机构：[a]Department of Ophthalmology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China[b]Department of Neurology, Xuan Wu Hospital of Capital Medical University, Beijing, China神经内科首都医科大学宣武医院[c]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China[d]Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China[e]Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, UK
Purpose/aim: We investigated the regularity changes of the retinal nerve fiber layer (RNFL) and macular ganglion cell complex (mGCC) of the amnestic mild cognitive impairment (aMCI) patients in this prospective cohort study.Materials and methods: Twenty-four aMCI patients and 30 health controls, who are more than 60years old, were recruited into the study. The RNFL and the mGCC average thickness were measured with Fourier-domain optical coherence tomography (FD-OCT).Results: Compared with that in the controls, the intraocular pressure (IOP) was significantly lower in the aMCI patients. A significant decrease in RNFL thickness in superior temporal, temporal upper (TU), and temporal upper and lower (TL) (TU+TL) quadrants was found in the aMCI patients than in the controls. The average thickness of the mGCC was also significantly thinner in the aMCI patients than in the controls.Conclusions: Retinal degeneration in the aMCI patients detected by OCT together with lower IOP may indicate disease pathological progression.
基金：
Beijing Municipal Science and Technology Commission [grant number Z141107002514116];
National Natural Science Foundation of China [grant number 31371007], [grant number 81430037], [grant number 30970823];
Kallikrein Medical Research Program [grant number201206006].
第一作者机构：[a]Department of Ophthalmology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[a]Department of Ophthalmology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Yue Wu,Xiao-Ni Wang,Ningli Wang,et al.Regularity changes of the retinal nerve fiber layer and macular ganglion cell complex in patients with the amnestic mild cognitive impairment[J].INTERNATIONAL JOURNAL OF NEUROSCIENCE.2018,128(9):849-853.doi:10.1080/00207454.2018.1438428.
APA：
Yue Wu,Xiao-Ni Wang,Ningli Wang,Ying Han,Daqing Ma&Yan Lu.(2018).Regularity changes of the retinal nerve fiber layer and macular ganglion cell complex in patients with the amnestic mild cognitive impairment.INTERNATIONAL JOURNAL OF NEUROSCIENCE,128,(9)
MLA：
Yue Wu,et al."Regularity changes of the retinal nerve fiber layer and macular ganglion cell complex in patients with the amnestic mild cognitive impairment".INTERNATIONAL JOURNAL OF NEUROSCIENCE 128..9(2018):849-853
