Individual Proportion Loss of Functional Connectivity Strength: A Novel Individual Functional Connectivity Biomarker for Subjective Cognitive Decline Populations
机构：[1]School of Communication and Information Engineering, Shanghai University, Shanghai 200444, China.[2]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou 646000, China.[3]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.神经科系统神经内科首都医科大学宣武医院[4]Institute of Biomedical Engineering, School of Life Science, Shanghai University, Shanghai 200444, China.[5]School of Biomedical Engineering, Hainan University, Haikou 570228, China.[6]Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing 100053, China.[7]National Clinical Research Center for Geriatric Disorders, Beijing 100053, China.
High individual variation in the subjective cognitive decline (SCD) population makes functional connectivity (FC) biomarkers unstable. This study proposed a novel individual FC index, named individual proportion loss of functional connectivity strength (IPLFCS), and explored potential biomarkers for SCD using this new index. We proposed an IPLFCS analysis framework and compared it with traditional FC in Chinese and Western cohorts. Post hoc tests were used to determine biomarkers. Pearson's correlation analysis was used to investigate the correlation between neuropsychological scores or cortical amyloid deposits and IPLFCS biomarkers. Receiver operating characteristic curves were utilized to evaluate the ability of potential biomarkers to distinguish between groups. IPLFCS of the left middle temporal gyrus (LMTG) was identified as a potential biomarker. The IPLFC was correlated with the traditional FC (r = 0.956, p < 0.001; r = 0.946, p < 0.001) and cortical amyloid deposition (r = -0.245, p = 0.029; r = -0.185, p = 0.048) in both cohorts. Furthermore, the IPLFCS decreased across the Alzheimer's disease (AD) continuum. Its diagnostic efficiency was superior to that of existing fMRI biomarkers. These findings suggest that IPLFCS of the LMTG could be a potential biomarker of SCD.
基金：
This work was supported by the National Natural Science Foundation of China (Grant
61633018, 82020108013), the Science and Technology Innovation 2030 Major Projects (2022ZD0211606),
and the Open Project Program of Nuclear Medicine and Molecular Imaging Key Laboratory of
Sichuan Province (HYX21004).
第一作者机构：[1]School of Communication and Information Engineering, Shanghai University, Shanghai 200444, China.[2]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou 646000, China.
共同第一作者：
通讯作者：
通讯机构：[2]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou 646000, China.[3]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.[4]Institute of Biomedical Engineering, School of Life Science, Shanghai University, Shanghai 200444, China.[5]School of Biomedical Engineering, Hainan University, Haikou 570228, China.[6]Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing 100053, China.[7]National Clinical Research Center for Geriatric Disorders, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Li Zhuoyuan,Lin Hua,Zhang Qi,et al.Individual Proportion Loss of Functional Connectivity Strength: A Novel Individual Functional Connectivity Biomarker for Subjective Cognitive Decline Populations[J].BIOLOGY-BASEL.2023,12(4):doi:10.3390/biology12040564.
APA：
Li Zhuoyuan,Lin Hua,Zhang Qi,Shi Rong,Xu Huanyu...&Jiang Jiehui.(2023).Individual Proportion Loss of Functional Connectivity Strength: A Novel Individual Functional Connectivity Biomarker for Subjective Cognitive Decline Populations.BIOLOGY-BASEL,12,(4)
MLA：
Li Zhuoyuan,et al."Individual Proportion Loss of Functional Connectivity Strength: A Novel Individual Functional Connectivity Biomarker for Subjective Cognitive Decline Populations".BIOLOGY-BASEL 12..4(2023)
