机构：[1]Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China.神经科系统神经内科首都医科大学宣武医院[2]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京友谊医院[3]Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.[4]Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China.[5]Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.[6]Department of Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China.[7]Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China.[8]Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany.[9]School of Biomedical Engineering, Hainan University, Haikou, China.[10]Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China.[11]National Clinical Research Center for Geriatric Disorders, Beijing, China.[12]The Central Hospital of Karamay, Xinjiang, China.
A range of imaging modalities have reported Alzheimer's disease-related abnormalities in individuals experiencing subjective cognitive decline (SCD). However, there has been no consistent local abnormality identified across multiple neuroimaging modalities for SCD.We aimed to investigate the convergent local alterations in amyloid-β (Aβ) deposition, glucose metabolism, and resting-state functional MRI (RS-fMRI) metrics in SCD.Fifty SCD patients (66.4±5.7 years old, 19 men [38%]) and 15 normal controls (NC) (66.3±4.4 years old, 5 men [33.3%]) were scanned with both [18F]-florbetapir PET and [18F]-fluorodeoxyglucose PET, as well as simultaneous RS-fMRI from February 2018 to November 2018. Voxel-wise metrics were retrospectively analyzed, including Aβ deposition, glucose metabolism, amplitude of low frequency fluctuation (ALFF), regional homogeneity (ReHo), and degree centrality(DC).The SCD group showed increased Aβ deposition and glucose metabolism (p < 0.05, corrected), as well as decreased ALFF, ReHo, and DC (p < 0.05, uncorrected) in the left dorsal precuneus (dPCu). Furthermore, the dPCu illustrated negative resting-state functional connectivity with the default mode network. Regarding global Aβ deposition positivity, the Aβ deposition in the left dPCu showed a gradient change, i.e., Aβ positive SCD > Aβ negative SCD > Aβ negative NC. Additionally, both Aβ positive SCD and Aβ negative SCD showed increased glucose metabolism and decreased RS-fMRI metrics in the dPCu.The dorsal precuneus, an area implicated in early AD, shows convergent neuroimaging alterations in SCD, and might be more related to other cognitive functions (e.g., unfocused attention) than episodic memory.
基金：
This work was supported by the National
Natural Science Foundation of China (grant numbers
82020108013, 82327809 and 81661148045),
STI2030-Major Projects (2022ZD0211800), and
Sino-German Cooperation Grant (M-0759), Shenzhen
Bay Scholars Program and Tianchi Scholars
Program.
第一作者机构：[1]Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China.[2]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China.[3]Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.[4]Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China.[5]Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.[7]Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China.[9]School of Biomedical Engineering, Hainan University, Haikou, China.[10]Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China.[11]National Clinical Research Center for Geriatric Disorders, Beijing, China.[12]The Central Hospital of Karamay, Xinjiang, China.
推荐引用方式(GB/T 7714)：
Li Xuan-Yu,Yuan Li-Xia,Ding Chang-Chang,et al.Convergent Multimodal Imaging Abnormalities in the Dorsal Precuneus in Subjective Cognitive Decline[J].Journal Of Alzheimer's Disease : JAD.2024,101(2):589-601.doi:10.3233/JAD-231360.
APA：
Li Xuan-Yu,Yuan Li-Xia,Ding Chang-Chang,Guo Teng-Fei,Du Wen-Ying...&Han Ying.(2024).Convergent Multimodal Imaging Abnormalities in the Dorsal Precuneus in Subjective Cognitive Decline.Journal Of Alzheimer's Disease : JAD,101,(2)
MLA：
Li Xuan-Yu,et al."Convergent Multimodal Imaging Abnormalities in the Dorsal Precuneus in Subjective Cognitive Decline".Journal Of Alzheimer's Disease : JAD 101..2(2024):589-601
