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Apolipoprotein E epsilon 4 accelerates the longitudinal cerebral atrophy in open access series of imaging studies-3 elders without dementia at enrollment

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机构: [1]Capital Med Univ, Dept Neurosurg, Xuanwu Hosp, Beijing, Peoples R China [2]Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin, Peoples R China [3]Capital Med Univ, Clin Res Ctr Epilepsy, Beijing, Peoples R China [4]Beijing Municipal Geriatr Med Res Ctr, Beijing, Peoples R China
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关键词: Alzheimer's disease cerebral atrophic apolipoprotein E aging dementia

摘要:
IntroductionEarly studies have reported that APOE is strongly associated with brain atrophy and cognitive decline among healthy elders and Alzheimer's disease (AD). However, previous research has not directly outlined the modulation of APOE on the trajectory of cerebral atrophy with aging during the conversion from cognitive normal (CN) to dementia (CN2D). MethodsThis study tried to elucidate this issue from a voxel-wise whole-brain perspective based on 416 qualified participants from a longitudinal OASIS-3 neuroimaging cohort. A voxel-wise linear mixed-effects model was applied for detecting cerebrum regions whose nonlinear atrophic trajectories were driven by AD conversion and to elucidate the effect of APOE variants on the cerebral atrophic trajectories during the process. ResultsWe found that CN2D participants had faster quadratically accelerated atrophy in bilateral hippocampi than persistent CN. Moreover, APOE epsilon 4 carriers had faster-accelerated atrophy in the left hippocampus than epsilon 4 noncarriers in both CN2D and persistent CN, and CN2D epsilon 4 carriers an noncarriers presented a faster atrophic speed than CN epsilon 4 carriers. These findings could be replicated in a sub-sample with a tough match in demographic information. DiscussionOur findings filled the gap that APOE epsilon 4 accelerates hippocampal atrophy and the conversion from normal cognition to dementia.

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出版当年[2022]版:
大类 | 2 区 医学
小类 | 3 区 神经科学 3 区 老年医学
最新[2023]版:
大类 | 2 区 医学
小类 | 3 区 老年医学 3 区 神经科学
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出版当年[2021]版:
Q1 NEUROSCIENCES Q2 GERIATRICS & GERONTOLOGY
最新[2023]版:
Q2 NEUROSCIENCES Q2 GERIATRICS & GERONTOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

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第一作者机构: [1]Capital Med Univ, Dept Neurosurg, Xuanwu Hosp, Beijing, Peoples R China
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通讯机构: [1]Capital Med Univ, Dept Neurosurg, Xuanwu Hosp, Beijing, Peoples R China [3]Capital Med Univ, Clin Res Ctr Epilepsy, Beijing, Peoples R China [4]Beijing Municipal Geriatr Med Res Ctr, Beijing, Peoples R China
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