Apolipoprotein E epsilon 4 accelerates the longitudinal cerebral atrophy in open access series of imaging studies-3 elders without dementia at enrollment
机构:[1]Capital Med Univ, Dept Neurosurg, Xuanwu Hosp, Beijing, Peoples R China首都医科大学宣武医院[2]Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin, Peoples R China[3]Capital Med Univ, Clin Res Ctr Epilepsy, Beijing, Peoples R China[4]Beijing Municipal Geriatr Med Res Ctr, Beijing, Peoples R China
IntroductionEarly studies have reported that APOE is strongly associated with brain atrophy and cognitive decline among healthy elders and Alzheimer's disease (AD). However, previous research has not directly outlined the modulation of APOE on the trajectory of cerebral atrophy with aging during the conversion from cognitive normal (CN) to dementia (CN2D). MethodsThis study tried to elucidate this issue from a voxel-wise whole-brain perspective based on 416 qualified participants from a longitudinal OASIS-3 neuroimaging cohort. A voxel-wise linear mixed-effects model was applied for detecting cerebrum regions whose nonlinear atrophic trajectories were driven by AD conversion and to elucidate the effect of APOE variants on the cerebral atrophic trajectories during the process. ResultsWe found that CN2D participants had faster quadratically accelerated atrophy in bilateral hippocampi than persistent CN. Moreover, APOE epsilon 4 carriers had faster-accelerated atrophy in the left hippocampus than epsilon 4 noncarriers in both CN2D and persistent CN, and CN2D epsilon 4 carriers an noncarriers presented a faster atrophic speed than CN epsilon 4 carriers. These findings could be replicated in a sub-sample with a tough match in demographic information. DiscussionOur findings filled the gap that APOE epsilon 4 accelerates hippocampal atrophy and the conversion from normal cognition to dementia.
基金:
National Natural Science Foundation of China [82030037, 81871009, 81971599, 81771818]; STI2030-Major Projects [2021ZD0201801]; Translational and Application Project of Brain-inspired and Network Neuroscience on Brain Disorders, Beijing Municipal Health Commission [11000022T000000444685]; Tianjin Natural Science Foundation [19JCYBJC25100]; NIH [P30 AG066444, P50 AG00561, P30 NS09857781, P01 AG026276, P01 AG003991, R01 AG043434, UL1 TR000448, R01 EB009352]
第一作者机构:[1]Capital Med Univ, Dept Neurosurg, Xuanwu Hosp, Beijing, Peoples R China
通讯作者:
通讯机构:[1]Capital Med Univ, Dept Neurosurg, Xuanwu Hosp, Beijing, Peoples R China[3]Capital Med Univ, Clin Res Ctr Epilepsy, Beijing, Peoples R China[4]Beijing Municipal Geriatr Med Res Ctr, Beijing, Peoples R China
推荐引用方式(GB/T 7714):
Huang Yuda,Shan Yongzhi,Qin Wen,et al.Apolipoprotein E epsilon 4 accelerates the longitudinal cerebral atrophy in open access series of imaging studies-3 elders without dementia at enrollment[J].FRONTIERS IN AGING NEUROSCIENCE.2023,15:doi:10.3389/fnagi.2023.1158579.
APA:
Huang, Yuda,Shan, Yongzhi,Qin, Wen&Zhao, Guoguang.(2023).Apolipoprotein E epsilon 4 accelerates the longitudinal cerebral atrophy in open access series of imaging studies-3 elders without dementia at enrollment.FRONTIERS IN AGING NEUROSCIENCE,15,
MLA:
Huang, Yuda,et al."Apolipoprotein E epsilon 4 accelerates the longitudinal cerebral atrophy in open access series of imaging studies-3 elders without dementia at enrollment".FRONTIERS IN AGING NEUROSCIENCE 15.(2023)