机构：[1]Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China, [2]Brain Aging and Cognitive Neuroscience Laboratory of Hebei Province, Shijiazhuang, Hebei, China, [3]Department of Neurology, Hebei Hospital of Xuanwu Hospital Capital Medical University, Shijiazhuang, Hebei, China, 神经科系统神经内科首都医科大学宣武医院[4]Department of Respiratory Medicine, Harrison International Peace Hospital, Hengshui, Hebei, China, [5]Department of Radiology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
IntroductionUnlike the effect of repetitive transcranial magnetic stimulation (rTMS) in treating neuropsychiatric diseases, little is known about how personal factors might account for the disparity of results from studies of cognition and rTMS. In this study, we investigated the effects of high-frequency rTMS on response inhibition control and explored the time course changes in cognitive processing and brain metabolic mechanisms after rTMS using event-related potentials (ERPs) and magnetic resonance spectroscopy (H-1-MRS). MethodsParticipants were all right-handed and were naive to rTMS and the Go/NoGo task. Twenty-five healthy young participants underwent one 10 Hz rTMS session per day in which stimulation was applied over the left dorsolateral prefrontal cortex (DLPFC), and a homogeneous participant group of 25 individuals received a sham rTMS treatment for 1 week. A Go/NoGo task was performed, an electroencephalogram (EEG) was recorded, and H-1-MRS was performed. ResultsThe results revealed that there was a strong trend of decreasing commission errors of NoGo stimuli by high frequency rTMS over the left DLPFC, whereas there was no significant difference between before and after rTMS treatment with respect to these parameters in the sham rTMS group. High-frequency rTMS significantly increased the amplitude of NoGo-N2 but not Go-N2, Go-P3, or NoGo-P3. The myo-inositol /creatine complex (MI/Cr) ratio, indexing cerebral metabolism, in the left DLPFC was decreased in the rTMS treated group. DiscussionThis observation supports the view that high-frequency rTMS over the left DLPFC has the strong tendency of reducing commission errors behaviorally, increase the amplitude of NoGo-N2 and improve the response inhibition control of healthy young participants. The results are consistent with the excitatory properties of high frequency rTMS. We suggest that the increase in the NoGo-N2 amplitude may be related to the increased excitability of the DLPFC-anterior cingulate cortex (ACC) neural loop. Metabolic changes in the DLPFC may be a possible mechanism for the improvement of the response inhibition control of rTMS.
基金：
key research and development of Hebei Province [172777221]; Spark Program [XH201705]
第一作者机构：[1]Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China, [2]Brain Aging and Cognitive Neuroscience Laboratory of Hebei Province, Shijiazhuang, Hebei, China, [3]Department of Neurology, Hebei Hospital of Xuanwu Hospital Capital Medical University, Shijiazhuang, Hebei, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China, [2]Brain Aging and Cognitive Neuroscience Laboratory of Hebei Province, Shijiazhuang, Hebei, China, [3]Department of Neurology, Hebei Hospital of Xuanwu Hospital Capital Medical University, Shijiazhuang, Hebei, China,
推荐引用方式(GB/T 7714)：
Li Yanmin,Pang Jianmin,Wang Jing,et al.High-frequency rTMS over the left DLPFC improves the response inhibition control of young healthy participants: an ERP combined H-1-MRS study[J].FRONTIERS IN PSYCHOLOGY.2023,14:doi:10.3389/fpsyg.2023.1144757.
APA：
Li, Yanmin,Pang, Jianmin,Wang, Jing,Wang, Wei,Bo, Qianlan...&Wang, Mingwei.(2023).High-frequency rTMS over the left DLPFC improves the response inhibition control of young healthy participants: an ERP combined H-1-MRS study.FRONTIERS IN PSYCHOLOGY,14,
MLA：
Li, Yanmin,et al."High-frequency rTMS over the left DLPFC improves the response inhibition control of young healthy participants: an ERP combined H-1-MRS study".FRONTIERS IN PSYCHOLOGY 14.(2023)
